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ENZYME entry: EC 1.2.1.2

Accepted Name
Formate dehydrogenase.
Reaction catalysed
Formate + NAD(+) <=> CO(2) + NADH
Cofactor(s)
Flavin; Iron-sulfur; Molybdenum.
Comment(s)
  • The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center.
  • Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase.
Cross-references
PROSITEPDOC00063 ; PDOC00392
BRENDA1.2.1.2
EC2PDB1.2.1.2
ExplorEnz1.2.1.2
PRIAM enzyme-specific profiles1.2.1.2
KEGG Ligand Database for Enzyme Nomenclature1.2.1.2
IUBMB Enzyme Nomenclature1.2.1.2
IntEnz1.2.1.2
MEDLINEFind literature relating to 1.2.1.2
MetaCyc1.2.1.2
UniProtKB/Swiss-Prot
Q9SXP2, FDH1_ORYSJ;  A6ZN46, FDH1_YEAS7;  C8ZHD6, FDH1_YEAS8;  
N1P3Y5, FDH1_YEASC;  Q08911, FDH1_YEAST;  Q67U69, FDH2_ORYSJ;  
P0CT22, FDH2_YEASC;  P0CF35, FDH2_YEAST;  Q934F5, FDHA_DESGI;  
P06131, FDHA_METFO;  P61159, FDHA_METJA;  P06130, FDHB_METFO;  
Q60316, FDHB_METJA;  Q50570, FDHB_METTF;  P07658, FDHF_ECOLI;  
Q795Y4, FDHL_BACSU;  Q2FEI5, FDHL_STAA3;  Q2FVV9, FDHL_STAA8;  
Q2YYT1, FDHL_STAAB;  Q5HDP9, FDHL_STAAC;  Q931G2, FDHL_STAAM;  
Q99RW4, FDHL_STAAN;  Q6GEC4, FDHL_STAAR;  Q6G711, FDHL_STAAS;  
Q7A057, FDHL_STAAW;  Q4L8G8, FDHL_STAHJ;  Q49ZN0, FDHL_STAS1;  
Q9S7E4, FDH_ARATH;  O13437, FDH_CANBO;  Q03134, FDH_EMENI;  
Q9ZRI8, FDH_HORVU;  Q07103, FDH_NEUCR;  P33677, FDH_PICAN;  
P33160, FDH_PSESR;  Q07511, FDH_SOLTU;  P32176, FDOG_ECOLI;  
P46448, FDXG_HAEIN;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-