ID   1.2.1.75
DE   malonyl CoA reductase (malonate semialdehyde-forming).
AN   malonyl CoA reductase (NADP).
AN   NADP-dependent malonyl CoA reductase.
CA   3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH.
CC   -!- Catalyzes the reduction of malonyl-CoA to malonate semialdehyde,
CC       a key step in the 3-hydroxypropanoate and the
CC       3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO2
CC       fixation pathways found in some green non-sulfur phototrophic
CC       bacteria and some thermoacidophilic archaea, respectively.
CC   -!- The enzyme from Sulfolobus tokodaii has been purified, and found to
CC       contain one RNA molecule per two subunits.
CC   -!- The enzyme from Chloroflexus aurantiacus is bifunctional, and also
CC       catalyzes the next reaction in the pathway, EC 1.1.1.298.
DR   A4YEN2, MCR_METS5  ;  Q96YK1, MCR_SULTO  ;
//