Due to improvement work scheduled on this server, some services may not be fully operational on Tuesday December 12 daytime (CEST).
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.2.1.88

Accepted Name
L-glutamate gamma-semialdehyde dehydrogenase.
Alternative Name(s)
1-pyrroline-5-carboxylate dehydrogenase.
Delta(1)-pyrroline-5-carboxylate dehydrogenase.
Pyrroline-5-carboxylate dehydrogenase.
Reaction catalysed
L-glutamate 5-semialdehyde + NAD(+) + H(2)O <=> L-glutamate + NADH
Comment(s)
  • This enzyme catalyzes the irreversible oxidation of glutamate-gamma- semialdehyde to glutamate as part of the proline degradation pathway.
  • (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde.
  • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
  • The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1- pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)- 1-pyrroline-5-carboxylate is converted into D-glutamate.
  • NADP(+) can also act as acceptor, but with lower activity.
  • Formerly EC 1.5.1.12.
Cross-references
PROSITEPDOC00068
BRENDA1.2.1.88
EC2PDB1.2.1.88
ExplorEnz1.2.1.88
PRIAM enzyme-specific profiles1.2.1.88
KEGG Ligand Database for Enzyme Nomenclature1.2.1.88
IUBMB Enzyme Nomenclature1.2.1.88
IntEnz1.2.1.88
MEDLINEFind literature relating to 1.2.1.88
MetaCyc1.2.1.88
UniProtKB/Swiss-Prot
Q8VZC3, AL121_ARATH;  A7YWE4, AL4A1_BOVIN;  Q7SY23, AL4A1_DANRE;  
Q54RA2, AL4A1_DICDI;  P30038, AL4A1_HUMAN;  Q8CHT0, AL4A1_MOUSE;  
P0C2X9, AL4A1_RAT;  P78568, PUT2_AGABI;  Q9P8I0, PUT2_EMENI;  
O74766, PUT2_SCHPO;  P07275, PUT2_YEAST;  P09546, PUTA_ECOLI;  
O52485, PUTA_KLEAE;  P23725, PUTA_KLEPN;  P95629, PUTA_RHIML;  
P10503, PUTA_SALTY;  Q9K9B2, ROCA1_BACHD;  Q9K5Z5, ROCA2_BACHD;  
P94391, ROCA2_BACSU;  B7GFV3, ROCA_ANOFW;  C3PBP4, ROCA_BACAA;  
C3L546, ROCA_BACAC;  A0R909, ROCA_BACAH;  Q81ZF8, ROCA_BACAN;  
B7JM99, ROCA_BACC0;  P62028, ROCA_BACC1;  B7IUW8, ROCA_BACC2;  
C1EV77, ROCA_BACC3;  B7H4V1, ROCA_BACC4;  B7HSW8, ROCA_BACC7;  
A7GKJ4, ROCA_BACCN;  B9J1L9, ROCA_BACCQ;  Q81IP0, ROCA_BACCR;  
Q63GS0, ROCA_BACCZ;  Q6HP91, ROCA_BACHK;  Q65NN2, ROCA_BACLD;  
A8F9T1, ROCA_BACP2;  P39634, ROCA_BACSU;  A9VRG6, ROCA_BACWK;  
Q5L3K8, ROCA_GEOKA;  C5D4J5, ROCA_GEOSW;  A4IJP9, ROCA_GEOTN;  
Q8ERF4, ROCA_OCEIH;  A7X6R7, ROCA_STAA1;  A6U4T5, ROCA_STAA2;  
Q2FDV3, ROCA_STAA3;  Q2FV67, ROCA_STAA8;  A5IVY0, ROCA_STAA9;  
Q2YWA6, ROCA_STAAB;  Q5HCZ6, ROCA_STAAC;  A6QK44, ROCA_STAAE;  
P63939, ROCA_STAAM;  P99076, ROCA_STAAN;  Q6GDP4, ROCA_STAAR;  
Q6G6C0, ROCA_STAAS;  A8Z3F5, ROCA_STAAT;  Q8NUR2, ROCA_STAAW;  
Q5HL59, ROCA_STAEQ;  Q8CN04, ROCA_STAES;  Q4L966, ROCA_STAHJ;  
Q4A0E7, ROCA_STAS1;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-