ENZYME entry: EC 1.2.3.1
| Accepted Name |
|---|
| Aldehyde oxidase.
|
| Alternative Name(s) |
|---|
| Quinoline oxidase. |
| Retinal oxidase. |
| Reaction catalysed |
|---|
| An aldehyde + H(2)O + O(2) <=> a carboxylate + H(2)O(2) |
| Cofactor(s) |
|---|
| FAD; Iron-sulfur; Molybdenum.
|
| Comment(s) |
|---|
- The enzyme from liver exhibits a broad substrate specificity, and is
involved in the metabolism of xenobiotics, including the oxidation of
N-heterocycles and aldehydes and the reduction of N-oxides,
nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic
hydrocarbons, and sulfoxides.
- The enzyme is also responsible for the oxidation of retinal,
an activity that was initially attributed to a distinct enzyme
(EC 1.2.3.11).
- Formerly EC 1.2.3.11.
|
| Cross-references |
|---|
| PROSITE | PDOC00484 |
| BRENDA | 1.2.3.1 |
| EC2PDB | 1.2.3.1 |
| ExplorEnz | 1.2.3.1 |
| PRIAM enzyme-specific profiles | 1.2.3.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.3.1 |
| IUBMB Enzyme Nomenclature | 1.2.3.1 |
| IntEnz | 1.2.3.1 |
| MEDLINE | Find literature relating to 1.2.3.1 |
| MetaCyc | 1.2.3.1 |
| UniProtKB/Swiss-Prot |
| P48034, ADO_BOVIN; | Q06278, ADO_HUMAN; | Q5FB27, ADO_MACFA; |
| O54754, ADO_MOUSE; | P80456, ADO_RABIT; | Q9Z0U5, ADO_RAT; |
| Q7XH05, ALDO1_ORYSJ; | Q852M1, ALDO2_ORYSJ; | Q852M2, ALDO3_ORYSJ; |
| Q69R21, ALDO4_ORYSJ; |
|
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