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ENZYME entry: EC 1.2.5.1

Accepted Name
Pyruvate dehydrogenase (quinone).
Alternative Name(s)
Pyruvate dehydrogenase.
Pyruvate dehydrogenase (cytochrome).
Pyruvate oxidase.
Reaction catalysed
Pyruvate + ubiquinone + H(2)O <=> acetate + CO(2) + ubiquinol
Cofactor(s)
FAD.
Comment(s)
  • This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone.
  • Does not accept menaquinone.
  • Activity is greatly enhanced by lipids.
  • Requires thiamine diphosphate.
  • The enzyme can also form acetoin.
Cross-references
BRENDA1.2.5.1
EC2PDB1.2.5.1
ExplorEnz1.2.5.1
PRIAM enzyme-specific profiles1.2.5.1
KEGG Ligand Database for Enzyme Nomenclature1.2.5.1
IUBMB Enzyme Nomenclature1.2.5.1
IntEnz1.2.5.1
MEDLINEFind literature relating to 1.2.5.1
MetaCyc1.2.5.1
UniProtKB/Swiss-Prot
P07003, POXB_ECOLI

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