ENZYME entry: EC 1.2.99.5

Accepted Name
Formylmethanofuran dehydrogenase.
Reaction catalysed
Formylmethanofuran + H(2)O + acceptor <=> CO(2) + methanofuran + reduced acceptor
Cofactor(s)
Mo cation.
Comment(s)
  • Tungstate can substitute for molybdate.
  • The enzyme catalyzes a reversible reaction in methanogenic bacteria, and is involved in methanogenesis from CO(2) as well as the oxidation of methyl-coenzyme M to CO(2).
  • Methyl viologen can act as acceptor.
  • Also oxidizes N-furfurylformamide.
Cross-references
BRENDA1.2.99.5
EC2PDB1.2.99.5
ExplorEnz1.2.99.5
PRIAM enzyme-specific profiles1.2.99.5
KEGG Ligand Database for Enzyme Nomenclature1.2.99.5
IUBMB Enzyme Nomenclature1.2.99.5
IntEnz1.2.99.5
MEDLINEFind literature relating to 1.2.99.5
MetaCyc1.2.99.5
UniProtKB/Swiss-Prot
Q48943, FMDC_METBF;  O27002, FMDC_METTH;  P61937, FMDC_METTM;  
P61938, FMDC_METWO;  P61154, FWDB_METJA;  Q6LWL8, FWDB_METMP;  
Q58571, FWDC_METJA;  P0CW42, FWDC_METMI;  P0CW43, FWDC_METMP;  
O27600, FWDC_METTH;  Q59579, FWDC_METTM;  O74031, FWDC_METWO;  
Q49611, FWDG_METKA;  

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