ENZYME entry: EC 1.21.4.4

Accepted Name
Betaine reductase.
Reaction catalysed
Acetyl phosphate + trimethylamine + thioredoxin disulfide + H(2)O <=> betaine + phosphate + thioredoxin
Comment(s)
  • The reaction is observed only in the direction of betaine reduction.
  • The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C.
  • Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release.
  • Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate.
  • Only subunit B distinguishes this enzyme from EC 1.21.4.2 and EC 1.21.4.3.
Cross-references
BRENDA1.21.4.4
EC2PDB1.21.4.4
ExplorEnz1.21.4.4
PRIAM enzyme-specific profiles1.21.4.4
KEGG Ligand Database for Enzyme Nomenclature1.21.4.4
IUBMB Enzyme Nomenclature1.21.4.4
IntEnz1.21.4.4
MEDLINEFind literature relating to 1.21.4.4
MetaCyc1.21.4.4
UniProtKB/Swiss-Prot
P50972, GRDA1_EUBAC;  Q6LH20, GRDA1_PHOPR;  O32518, GRDA2_EUBAC;  
Q6LH19, GRDA2_PHOPR;  A6TU46, GRDA_ALKMQ;  Q3A9J5, GRDA_CARHZ;  
A7FTE0, GRDA_CLOB1;  A7GCV1, GRDA_CLOBL;  P52216, GRDA_CLOLI;  
P26970, GRDA_CLOPU;  P26971, GRDA_CLOSD;  Q67KE6, GRDA_SYMTH;  
Q73PQ2, GRDA_TREDE;  P54935, GRDC_EUBAC;  Q47878, GRDD_EUBAC;  
O69407, GRDH_EUBAC;  O69406, GRDI_EUBAC;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.4.-
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