ENZYME entry: EC 1.21.4.4

Accepted Name
Betaine reductase.
Reaction catalysed
Acetyl phosphate + trimethylamine + thioredoxin disulfide + H(2)O <=> betaine + phosphate + thioredoxin
Comment(s)
  • The reaction is observed only in the direction of betaine reduction.
  • The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C.
  • Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release.
  • Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate.
  • Only subunit B distinguishes this enzyme from EC 1.21.4.2 and EC 1.21.4.3.
Cross-references
BRENDA1.21.4.4
EC2PDB1.21.4.4
ExplorEnz1.21.4.4
PRIAM enzyme-specific profiles1.21.4.4
KEGG Ligand Database for Enzyme Nomenclature1.21.4.4
IUBMB Enzyme Nomenclature1.21.4.4
IntEnz1.21.4.4
MEDLINEFind literature relating to 1.21.4.4
MetaCyc1.21.4.4
UniProtKB/Swiss-Prot
P50972, GRDA1_PEPAC;  Q6LH20, GRDA1_PHOPR;  O32518, GRDA2_PEPAC;  
Q6LH19, GRDA2_PHOPR;  P26971, GRDA_ACESD;  A6TU46, GRDA_ALKMQ;  
Q3A9J5, GRDA_CARHZ;  A7FTE0, GRDA_CLOB1;  A7GCV1, GRDA_CLOBL;  
P26970, GRDA_CLOPU;  P52216, GRDA_PEPLI;  Q67KE6, GRDA_SYMTH;  
Q73PQ2, GRDA_TREDE;  P54935, GRDC_PEPAC;  Q47878, GRDD_PEPAC;  
O69407, GRDH_PEPAC;  O69406, GRDI_PEPAC;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-