ID   1.21.98.4
DE   PqqA peptide cyclase.
CA   [PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine +
CA   E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine.
CC   -!- This bacterial enzyme, which is a member of the radical SAM protein
CC       family, catalyzes the formation of a C-C bond between C-4 of
CC       glutamate and C-3 of tyrosine residues of the PqqA protein (which are
CC       separated by three amino acid residues).
CC   -!- This is the first enzymic step in the biosynthesis of the bacterial
CC       enzyme cofactor pyrroloquinoline quinone (PQQ).
CC   -!- The reaction is dependent on the presence of flavodoxin and the
CC       accessory protein PqqD.
DR   Q6F9I9, PQQE_ACIAD ;  B7H2Y0, PQQE_ACIB3 ;  B7I6M8, PQQE_ACIB5 ;
DR   B2I0I5, PQQE_ACIBC ;  B0VQD7, PQQE_ACIBS ;  B0V494, PQQE_ACIBY ;
DR   P07782, PQQE_ACICA ;  C1DEW5, PQQE_AZOVD ;  Q89FG1, PQQE_BRADU ;
DR   B2VL10, PQQE_ERWT9 ;  Q9L3B0, PQQE_GLUOX ;  Q0BQS8, PQQE_GRABC ;
DR   B5XX58, PQQE_KLEP3 ;  A6T9H2, PQQE_KLEP7 ;  P27507, PQQE_KLEPN ;
DR   P59748, PQQE_KLUIN ;  B7KXC6, PQQE_METC4 ;  Q608P0, PQQE_METCA ;
DR   P71517, PQQE_METEA ;  A9W3R0, PQQE_METEP ;  B8ITV7, PQQE_METNO ;
DR   B1ZIB2, PQQE_METPB ;  B1LUE7, PQQE_METRJ ;  B0UE13, PQQE_METS4 ;
DR   B8ENI9, PQQE_METSB ;  Q48CT3, PQQE_PSE14 ;  B7VAB6, PQQE_PSEA8 ;
DR   Q02LD6, PQQE_PSEAB ;  Q9I2C0, PQQE_PSEAE ;  Q4K4U8, PQQE_PSEF5 ;
DR   A4XTR4, PQQE_PSEMY ;  A5VXG4, PQQE_PSEP1 ;  Q88QV8, PQQE_PSEPK ;
DR   Q88A84, PQQE_PSESM ;  Q4ZMC1, PQQE_PSEU2 ;  Q01060, PQQE_PSEVU ;
DR   O33506, PQQE_RAHAQ ;  Q9EXU8, PQQE_RHIME ;  Q6N8F3, PQQE_RHOPA ;
DR   Q5LTB4, PQQE_RUEPO ;  P59749, PQQE_STRRO ;  Q8PHY1, PQQE_XANAC ;
DR   Q3BQI4, PQQE_XANC5 ;  Q4UXI4, PQQE_XANC8 ;  B0RQ25, PQQE_XANCB ;
DR   Q8P6M7, PQQE_XANCP ;  Q2P4Y9, PQQE_XANOM ;  B2SSW3, PQQE_XANOP ;
DR   Q5H234, PQQE_XANOR ;
//