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ENZYME

ENZYME entry: EC 1.21.99.3

Accepted Name
thyroxine 5-deiodinase
Alternative Name(s)
diiodothyronine 5'-deiodinase
iodothyronine 5-deiodinase
iodothyronine inner ring monodeiodinase
type III iodothyronine deiodinase
Reaction catalysed
3,3',5'-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine
Comment(s)
  • The enzyme activity has only been demonstrated in the direction of 5-deiodination.
  • This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
  • Formerly EC 1.97.1.11.
Cross-references
BRENDA1.21.99.3
EC2PDB1.21.99.3
ExplorEnz1.21.99.3
PRIAM enzyme-specific profiles1.21.99.3
KEGG Ligand Database for Enzyme Nomenclature1.21.99.3
IUBMB Enzyme Nomenclature1.21.99.3
IntEnz1.21.99.3
MEDLINEFind literature relating to 1.21.99.3
MetaCyc1.21.99.3
Rhea expert-curated reactions1.21.99.3
UniProtKB/Swiss-Prot
P49898, IOD3_AQUCTQ5I3B1, IOD3_BOVINO42412, IOD3_CHICK
P55073, IOD3_HUMANQ91ZI8, IOD3_MOUSEQ6QN11, IOD3_PIG
P49897, IOD3_RATQ6DN07, IOD3_SHEEPA7YD35, IOD3_SPAAU
P49899, IOD3_XENLA

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