ID   1.21.99.3
DE   thyroxine 5-deiodinase.
AN   diiodothyronine 5'-deiodinase.
AN   iodothyronine 5-deiodinase.
AN   iodothyronine inner ring monodeiodinase.
AN   type III iodothyronine deiodinase.
CA   3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2.
CC   -!- The enzyme activity has only been demonstrated in the direction of
CC       5-deiodination.
CC   -!- This removal of the 5-iodine, i.e. from the inner ring, largely
CC       inactivates the hormone thyroxine.
CC   -!- Formerly EC 1.97.1.11.
DR   P49894, IOD1_CANLF ;  O42411, IOD1_CHICK ;  Q6V915, IOD1_FELCA ;
DR   P49895, IOD1_HUMAN ;  Q61153, IOD1_MOUSE ;  Q6QN13, IOD1_PIG   ;
DR   A4GT88, IOD1_RABIT ;  P24389, IOD1_RAT   ;  Q95N00, IOD1_SUNMU ;
DR   Q2QEI3, IOD1_XENLA ;  P49898, IOD3_AQUCT ;  Q5I3B1, IOD3_BOVIN ;
DR   O42412, IOD3_CHICK ;  P55073, IOD3_HUMAN ;  Q91ZI8, IOD3_MOUSE ;
DR   Q6QN11, IOD3_PIG   ;  P49897, IOD3_RAT   ;  Q6DN07, IOD3_SHEEP ;
DR   A7YD35, IOD3_SPAAU ;  P49899, IOD3_XENLA ;
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