ENZYME entry: EC 1.3.1.21

Accepted Name
7-dehydrocholesterol reductase.
Alternative Name(s)
7-dehydrocholesterol dehydrogenase/cholesterol oxidase.
7-DHC reductase.
Delta(7)-sterol reductase.
Sterol Delta(7)-reductase.
Reaction catalysed
Cholesterol + NADP(+) <=> cholesta-5,7-dien-3-beta-ol + NADPH
Comment(s)
  • In mammals the enzyme is part of the cholesterol biosynthesis pathway and catalyzes the reduction reaction.
  • In the nematode Caenorhabditis elegans the enzyme catalyzes the oxidation reaction as part of the biosynthesis of dafachronic acids that are important for control of developmental timing and longevity.
Cross-references
BRENDA1.3.1.21
EC2PDB1.3.1.21
ExplorEnz1.3.1.21
PRIAM enzyme-specific profiles1.3.1.21
KEGG Ligand Database for Enzyme Nomenclature1.3.1.21
IUBMB Enzyme Nomenclature1.3.1.21
IntEnz1.3.1.21
MEDLINEFind literature relating to 1.3.1.21
MetaCyc1.3.1.21
UniProtKB/Swiss-Prot
Q17938, DAF36_CAEEL;  Q5E9J5, DHCR7_BOVIN;  Q7SXF1, DHCR7_DANRE;  
Q9UBM7, DHCR7_HUMAN;  Q5UQI4, DHCR7_MIMIV;  O88455, DHCR7_MOUSE;  
Q9Z2Z8, DHCR7_RAT;  Q7ZXH1, DHCR7_XENLA;  Q6P4M0, DHCR7_XENTR;  
Q9LDU6, ST7R_ARATH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
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