ID   1.3.1.22
DE   3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)).
AN   3-oxo-5alpha-steroid 4-dehydrogenase.
AN   cholestenone 5alpha-reductase.
CA   a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) +
CA   NADPH.
CC   -!- The enzyme catalyzes the conversion of assorted 3-oxo-Delta(4)
CC       steroids into their corresponding 5alpha form.
CC   -!- Substrates for the mammalian enzyme include testosterone,
CC       progesterone, and corticosterone.
CC   -!- Substrates for the plant enzyme are brassinosteroids such as campest-
CC       4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5.
CC   -!- Formerly EC 1.3.1.4 and EC 1.3.1.30.
DR   Q38944, DET2_ARATH ;  I1HTF7, DET2_BRADI ;  Q2QDF6, DET2_GOSHI ;
DR   Q5K2N1, DET2_SOLLC ;  D2HBV9, PORED_AILME;  Q5RIU9, PORED_DANRE;
DR   Q9H8P0, PORED_HUMAN;  C7T2J9, PORED_MESAU;  Q9WUP4, PORED_MOUSE;
DR   Q5RJM1, PORED_RAT  ;  Q8AVI9, PORED_XENLA;  Q0P4J9, PORED_XENTR;
DR   A5PJS2, S5A1_BOVIN ;  P18405, S5A1_HUMAN ;  Q28891, S5A1_MACFA ;
DR   Q68FF9, S5A1_MOUSE ;  P24008, S5A1_RAT   ;  P31213, S5A2_HUMAN ;
DR   Q28892, S5A2_MACFA ;  Q99N99, S5A2_MOUSE ;  O18765, S5A2_PIG   ;
DR   P31214, S5A2_RAT   ;
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