ID   1.3.1.76
DE   precorrin-2 dehydrogenase.
AN   precorrin-2 oxidase.
CA   NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin.
CC   -!- Catalyzes the second of three steps leading to the formation of
CC       siroheme from uroporphyrinogen III.
CC   -!- The first step involves the donation of two S-adenosyl-L-methionine-
CC       derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to
CC       form precorrin-2 (EC 2.1.1.107) and the third step involves the
CC       chelation of ferrous iron to sirohydrochlorin to form siroheme
CC       (EC 4.99.1.4).
CC   -!- In Saccharomyces cerevisiae, the last two steps are carried out by a
CC       single bifunctional enzyme, Met8p.
CC   -!- In some bacteria, steps 1-3 are catalyzed by a single multifunctional
CC       protein called CysG, whereas in Bacillus megaterium, three separate
CC       enzymes carry out each of the steps, with SirC being responsible for
CC       the above reaction.
DR   A0KLD7, CYSG1_AERHH;  A4SHL4, CYSG1_AERS4;  A7MJ67, CYSG1_CROS8;
DR   A1WWP8, CYSG1_HALHL;  A6TD45, CYSG1_KLEP7;  Q6D1A4, CYSG1_PECAS;
DR   A8G9Y3, CYSG1_SERP5;  A1JJS8, CYSG1_YERE8;  A7FLY4, CYSG1_YERP3;
DR   Q1CLS2, CYSG1_YERPN;  A4TGU8, CYSG1_YERPP;  Q66EC9, CYSG1_YERPS;
DR   A0KP37, CYSG2_AERHH;  A4SRH0, CYSG2_AERS4;  A7MKK9, CYSG2_CROS8;
DR   A1WYD5, CYSG2_HALHL;  A6TF07, CYSG2_KLEP7;  Q6CZS0, CYSG2_PECAS;
DR   A8GKQ1, CYSG2_SERP5;  A1JSB7, CYSG2_YERE8;  A7FNS9, CYSG2_YERP3;
DR   Q1CCP6, CYSG2_YERPN;  A4TPZ1, CYSG2_YERPP;  Q664M6, CYSG2_YERPS;
DR   A0KQJ4, CYSG3_AERHH;  Q6F8G6, CYSG_ACIAD ;  B3GZA0, CYSG_ACTP7 ;
DR   B0BTC2, CYSG_ACTPJ ;  A6VPZ6, CYSG_ACTSZ ;  Q0VQ05, CYSG_ALCBS ;
DR   Q0A812, CYSG_ALKEH ;  C1DKY7, CYSG_AZOVD ;  Q1LTP4, CYSG_BAUCH ;
DR   Q7VQG9, CYSG_BLOFL ;  Q493N1, CYSG_BLOPB ;  Q2KWB0, CYSG_BORA1 ;
DR   Q7WMM4, CYSG_BORBR ;  Q7WB57, CYSG_BORPA ;  A9HZV6, CYSG_BORPD ;
DR   Q7VZ77, CYSG_BORPE ;  P57500, CYSG_BUCAI ;  Q7NZV7, CYSG_CHRVO ;
DR   A8AQS4, CYSG_CITK8 ;  A7ZSP4, CYSG_ECO24 ;  B7UK79, CYSG_ECO27 ;
DR   B7MCY5, CYSG_ECO45 ;  B7L4P2, CYSG_ECO55 ;  P0AEA9, CYSG_ECO57 ;
DR   B5YTS6, CYSG_ECO5E ;  B7NMD7, CYSG_ECO7I ;  B7N1F1, CYSG_ECO81 ;
DR   B7M1S1, CYSG_ECO8A ;  C4ZUM4, CYSG_ECOBW ;  B1X716, CYSG_ECODH ;
DR   A8A5H5, CYSG_ECOHS ;  A1AGQ2, CYSG_ECOK1 ;  Q0TC92, CYSG_ECOL5 ;
DR   Q8FCW8, CYSG_ECOL6 ;  B1IP96, CYSG_ECOLC ;  P0AEA8, CYSG_ECOLI ;
DR   B7NDX8, CYSG_ECOLU ;  B6I2S7, CYSG_ECOSE ;  B1LHG9, CYSG_ECOSM ;
DR   Q1R5R3, CYSG_ECOUT ;  C5BGP8, CYSG_EDWI9 ;  A4WFH1, CYSG_ENT38 ;
DR   B7LS75, CYSG_ESCF3 ;  A9H259, CYSG_GLUDA ;  Q5FP95, CYSG_GLUOX ;
DR   Q2SJB7, CYSG_HAHCH ;  Q31GG8, CYSG_HYDCU ;  Q65T49, CYSG_MANSM ;
DR   Q606C9, CYSG_METCA ;  Q1H3L5, CYSG_METFK ;  A9LZ77, CYSG_NEIM0 ;
DR   P57001, CYSG_NEIMA ;  P95370, CYSG_NEIMB ;  A1KU10, CYSG_NEIMF ;
DR   Q0AHC1, CYSG_NITEC ;  Q820Q4, CYSG_NITEU ;  Q2Y6L7, CYSG_NITMU ;
DR   Q3JCS0, CYSG_NITOC ;  Q7N8L2, CYSG_PHOLL ;  Q6LM67, CYSG_PHOPR ;
DR   Q48H75, CYSG_PSE14 ;  Q15YU1, CYSG_PSEA6 ;  A6V4H6, CYSG_PSEA7 ;
DR   B7UW11, CYSG_PSEA8 ;  Q02NA3, CYSG_PSEAB ;  Q9I0M7, CYSG_PSEAE ;
DR   Q1IBC9, CYSG_PSEE4 ;  Q4K9V8, CYSG_PSEF5 ;  C3JY53, CYSG_PSEFS ;
DR   A4XUX3, CYSG_PSEMY ;  A5W1H7, CYSG_PSEP1 ;  Q3KA85, CYSG_PSEPF ;
DR   Q88FT3, CYSG_PSEPK ;  B1JBD9, CYSG_PSEPW ;  Q87ZT0, CYSG_PSESM ;
DR   Q3ILQ9, CYSG_PSET1 ;  Q4ZRL6, CYSG_PSEU2 ;  Q4FSU1, CYSG_PSYA2 ;
DR   Q1QAX7, CYSG_PSYCK ;  A1SRP9, CYSG_PSYIN ;  A5WEG6, CYSG_PSYWF ;
DR   A1AVU5, CYSG_RUTMC ;  Q21K21, CYSG_SACD2 ;  B5F8J0, CYSG_SALA4 ;
DR   A9MME5, CYSG_SALAR ;  Q57IZ5, CYSG_SALCH ;  B5FJQ1, CYSG_SALDC ;
DR   B5R2C7, CYSG_SALEP ;  B5R7N6, CYSG_SALG2 ;  B4TKQ4, CYSG_SALHS ;
DR   B4SVI1, CYSG_SALNS ;  Q5PLV8, CYSG_SALPA ;  A9MT45, CYSG_SALPB ;
DR   C0Q0F3, CYSG_SALPC ;  B5BH22, CYSG_SALPK ;  B4TY38, CYSG_SALSV ;
DR   Q8Z201, CYSG_SALTI ;  P25924, CYSG_SALTY ;  B2U3H4, CYSG_SHIB3 ;
DR   Q31VS0, CYSG_SHIBS ;  Q32AZ8, CYSG_SHIDS ;  Q0SZU8, CYSG_SHIF8 ;
DR   Q83JB3, CYSG_SHIFL ;  Q3YWQ3, CYSG_SHISS ;  Q2NVN0, CYSG_SODGM ;
DR   A4VLU6, CYSG_STUS1 ;  Q3SG32, CYSG_THIDA ;  B8GUD3, CYSG_THISH ;
DR   C4LAG5, CYSG_TOLAT ;  A5CXE4, CYSG_VESOH ;  B2I985, CYSG_XYLF2 ;
DR   Q9PF46, CYSG_XYLFA ;  B0U4X0, CYSG_XYLFM ;  Q87AI5, CYSG_XYLFT ;
DR   Q1C2P9, CYSG_YERPA ;  Q74Y23, CYSG_YERPE ;  Q5NRM4, CYSG_ZYMMO ;
DR   Q59292, HEMA_RUMJO ;  O14172, MET8_SCHPO ;  P15807, MET8_YEAST ;
DR   Q46CH4, PC2DH_METBF;  Q57605, PC2DH_METJA;  O34813, SIRC_BACSU ;
DR   P61818, SIRC_PRIMG ;
//