ENZYME entry: EC 1.3.1.77

Accepted Name
Anthocyanidin reductase ((2R,3R)-flavan-3-ol-forming).
Alternative Name(s)
ANR.
Anthocyanidin reductase.
Reaction catalysed
A (2R,3R)-flavan-3-ol + 2 NAD(P)(+) <=> an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H
Comment(s)
  • The enzyme participates in the flavonoid biosynthesis pathway found in plants.
  • It catalyzes the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins.
  • While the enzyme from the legume Medicago truncatula can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana uses only NADPH.
  • Also, while the substrate preference of the M.truncatula is cyanidin>pelargonidin>delphinidin, the reverse preference is found with the Arabidopsis enzyme.
  • Cf. EC 1.3.1.112.
Cross-references
BRENDA1.3.1.77
EC2PDB1.3.1.77
ExplorEnz1.3.1.77
PRIAM enzyme-specific profiles1.3.1.77
KEGG Ligand Database for Enzyme Nomenclature1.3.1.77
IUBMB Enzyme Nomenclature1.3.1.77
IntEnz1.3.1.77
MEDLINEFind literature relating to 1.3.1.77
MetaCyc1.3.1.77
UniProtKB/Swiss-Prot
Q9SEV0, BAN_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
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