ENZYME entry: EC 1.3.1.82

Accepted Name
(-)-isopiperitenone reductase.
Reaction catalysed
(+)-cis-isopulegone + NADP(+) <=> (-)-isopiperitenone + NADPH
Comment(s)
  • The reaction occurs in the opposite direction to that shown above.
  • Participates in the menthol-biosynthesis pathway of Mentha plants.
  • (+)-pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates.
  • Has a preference for NADPH as the reductant, with NADH being a poor substitute.
  • Highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product.
Cross-references
PROSITEPDOC00060
BRENDA1.3.1.82
EC2PDB1.3.1.82
ExplorEnz1.3.1.82
PRIAM enzyme-specific profiles1.3.1.82
KEGG Ligand Database for Enzyme Nomenclature1.3.1.82
IUBMB Enzyme Nomenclature1.3.1.82
IntEnz1.3.1.82
MEDLINEFind literature relating to 1.3.1.82
MetaCyc1.3.1.82
UniProtKB/Swiss-Prot
Q6WAU1, IPIPR_MENPI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-