ENZYME entry: EC 1.3.1.85

Accepted Name
Crotonyl-CoA carboxylase/reductase.
Alternative Name(s)
CCR.
Crotonyl-CoA reductase (carboxylating).
Reaction catalysed
(2S)-ethylmalonyl-CoA + NADP(+) <=> (E)-but-2-enoyl-CoA + CO(2) + NADPH
Comment(s)
  • The reaction is catalyzed in the reverse direction.
  • This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyzes (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO(2).
  • When CO(2) is absent, the enzyme catalyzes the reduction of (E)-but- 2-enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation).
Cross-references
BRENDA1.3.1.85
EC2PDB1.3.1.85
ExplorEnz1.3.1.85
PRIAM enzyme-specific profiles1.3.1.85
KEGG Ligand Database for Enzyme Nomenclature1.3.1.85
IUBMB Enzyme Nomenclature1.3.1.85
IntEnz1.3.1.85
MEDLINEFind literature relating to 1.3.1.85
MetaCyc1.3.1.85

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