ENZYME entry: EC 1.3.5.1

Accepted Name
Succinate dehydrogenase (quinone).
Alternative Name(s)
Succinate dehydrogenase (ubiquinone).
Succinic dehydrogenase.
Reaction catalysed
Succinate + a quinone <=> fumarate + a quinol
Cofactor(s)
FAD; Iron-sulfur.
Comment(s)
  • The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria.
  • It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II).
  • Eukaryotic enzymes utilize ubioquinone while bacterial enzymes utilize either ubiquinone or menaquinone, depending on the organism.
  • Cf. EC 1.3.5.4.
Cross-references
PROSITEPDOC00393
BRENDA1.3.5.1
EC2PDB1.3.5.1
ExplorEnz1.3.5.1
PRIAM enzyme-specific profiles1.3.5.1
KEGG Ligand Database for Enzyme Nomenclature1.3.5.1
IUBMB Enzyme Nomenclature1.3.5.1
IntEnz1.3.5.1
MEDLINEFind literature relating to 1.3.5.1
MetaCyc1.3.5.1
UniProtKB/Swiss-Prot
P0AC49, FRDB_ECO57;  P0AC48, FRDB_ECOL6;  P0AC47, FRDB_ECOLI;  
P44893, FRDB_HAEIN;  Q9ZMP1, FRDB_HELPJ;  O06914, FRDB_HELPY;  
P9WN88, FRDB_MYCTO;  P9WN89, FRDB_MYCTU;  P20921, FRDB_PROVU;  
P0AC50, FRDB_SHIFL;  P17596, FRDB_WOLSU;  O82663, SDHA1_ARATH;  
Q9ZPX5, SDHA2_ARATH;  Q6PA58, SDHAA_XENLA;  Q801S2, SDHAB_XENLA;  
P08065, SDHA_BACSU;  P31039, SDHA_BOVIN;  Q09508, SDHA_CAEEL;  
Q9YHT1, SDHA_CHICK;  P51054, SDHA_COXBU;  Q7ZVF3, SDHA_DANRE;  
Q9U3X4, SDHA_DICDI;  Q94523, SDHA_DROME;  P0AC43, SDHA_ECO57;  
P0AC42, SDHA_ECOL6;  P0AC41, SDHA_ECOLI;  P31040, SDHA_HUMAN;  
Q8HXW3, SDHA_MACFA;  Q0QF17, SDHA_MESAU;  Q8K2B3, SDHA_MOUSE;  
Q6ZDY8, SDHA_ORYSJ;  Q59661, SDHA_PARDE;  Q0QF01, SDHA_PIG;  
Q5R616, SDHA_PONAB;  Q920L2, SDHA_RAT;  Q1RHB9, SDHA_RICBR;  
Q92J97, SDHA_RICCN;  Q4UJM1, SDHA_RICFE;  P31038, SDHA_RICPR;  
Q68XN9, SDHA_RICTY;  Q8ZQU3, SDHA_SALTY;  Q9UTJ7, SDHA_SCHPO;  
Q28ED0, SDHA_XENTR;  Q00711, SDHA_YEAST;  Q8LBZ7, SDHB1_ARATH;  
Q8LB02, SDHB2_ARATH;  Q9FJP9, SDHB3_ARATH;  Q75CI4, SDHB_ASHGO;  
P08066, SDHB_BACSU;  Q3T189, SDHB_BOVIN;  A8WPF0, SDHB_CAEBR;  
Q09545, SDHB_CAEEL;  Q6FWS8, SDHB_CANGA;  Q9YHT2, SDHB_CHICK;  
P48932, SDHB_CHOCR;  P51053, SDHB_COXBU;  P48933, SDHB_CYACA;  
A5PL98, SDHB_DANRE;  Q55CC2, SDHB_DICDI;  P21914, SDHB_DROME;  
P07014, SDHB_ECOLI;  P21912, SDHB_HUMAN;  Q9CQA3, SDHB_MOUSE;  
O42772, SDHB_MYCGR;  Q59662, SDHB_PARDE;  Q007T0, SDHB_PIG;  
P80477, SDHB_PORPU;  P21913, SDHB_RAT;  P80480, SDHB_RECAM;  
Q1RGP3, SDHB_RICBR;  Q92JJ8, SDHB_RICCN;  Q4UN71, SDHB_RICFE;  
Q9ZEA1, SDHB_RICPR;  Q68XS0, SDHB_RICTY;  Q8ZQU2, SDHB_SALTY;  
P21911, SDHB_SCHPO;  Q70KF8, SDHB_UROFA;  P32420, SDHB_USTMA;  
Q3B8J8, SDHB_XENLA;  B0BM36, SDHB_XENTR;  P21801, SDHB_YEAST;  
P47052, SDHX_YEAST;  

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