ID   1.3.5.2
DE   dihydroorotate dehydrogenase (quinone).
AN   DHOD.
AN   DHOdehase.
AN   DHODH.
CA   (S)-dihydroorotate + a quinone = a quinol + orotate.
CC   -!- This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
CC   -!- The enzyme is found in eukaryotes in the mitochondrial membrane,
CC       in cyanobacteria, and in some Gram-negative and Gram-positive
CC       bacteria associated with the cytoplasmic membrane.
CC   -!- The reaction is the only redox reaction in the de-novo biosynthesis
CC       of pyrimidine nucleotides.
CC   -!- The best quinone electron acceptors for the enzyme from bovine liver
CC       are ubiquinone-6 and ubiquinone-7, although simple quinones, such as
CC       benzoquinone, can also act as acceptor at lower rates.
CC   -!- Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also
CC       substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and
CC       (S)-1,3-dimethyldihydroorotates are not.
CC   -!- Class 1 dihydroorotate dehydrogenases use either fumarate
CC       (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as
CC       electron acceptor.
CC   -!- Formerly EC 1.3.99.11.
DR   Q6CTX8, PYRD2_KLULA;  Q6SZS6, PYRD2_KLUMA;  B0CA74, PYRD_ACAM1 ;
DR   Q6FCL9, PYRD_ACIAD ;  B7GZW7, PYRD_ACIB3 ;  B7I2L5, PYRD_ACIB5 ;
DR   B2HUT6, PYRD_ACIBC ;  B0VKB8, PYRD_ACIBS ;  A3M6Y2, PYRD_ACIBT ;
DR   B0V824, PYRD_ACIBY ;  B9MIU2, PYRD_ACIET ;  B7J5Q1, PYRD_ACIF2 ;
DR   B5EL46, PYRD_ACIF5 ;  A1W7S6, PYRD_ACISJ ;  A3N0D6, PYRD_ACTP2 ;
DR   B3H1B5, PYRD_ACTP7 ;  B0BP55, PYRD_ACTPJ ;  A6VP48, PYRD_ACTSZ ;
DR   A0KKK9, PYRD_AERHH ;  A4SME2, PYRD_AERS4 ;  A9CK85, PYRD_AGRFC ;
DR   B2UNA2, PYRD_AKKM8 ;  Q21WC4, PYRD_ALBFT ;  Q5E5B6, PYRD_ALIF1 ;
DR   B5FE17, PYRD_ALIFM ;  B6ELD1, PYRD_ALISL ;  Q0A8M5, PYRD_ALKEH ;
DR   B9JR03, PYRD_ALLAM ;  B8JDF0, PYRD_ANAD2 ;  Q2IQI6, PYRD_ANADE ;
DR   A7HD76, PYRD_ANADF ;  B4UG99, PYRD_ANASK ;  P32746, PYRD_ARATH ;
DR   Q5P1A9, PYRD_AROAE ;  A0JX31, PYRD_ARTS2 ;  A8HZX8, PYRD_AZOC5 ;
DR   A1K7M2, PYRD_AZOSB ;  C1DDY1, PYRD_AZOVD ;  A1URL3, PYRD_BARBK ;
DR   Q6G4F7, PYRD_BARHE ;  Q6G159, PYRD_BARQU ;  A9IQ81, PYRD_BART1 ;
DR   Q1LT62, PYRD_BAUCH ;  Q2KW44, PYRD_BORA1 ;  Q7WGE4, PYRD_BORBR ;
DR   Q7W4W6, PYRD_BORPA ;  A9I8M0, PYRD_BORPD ;  Q7VTR9, PYRD_BORPE ;
DR   Q5E9W3, PYRD_BOVIN ;  Q89VA7, PYRD_BRADU ;  A5EA61, PYRD_BRASB ;
DR   A4Z2G7, PYRD_BRASO ;  B2S953, PYRD_BRUA1 ;  Q2YPG3, PYRD_BRUA2 ;
DR   A6WVY1, PYRD_BRUA4 ;  Q57F47, PYRD_BRUAB ;  A9M7Z9, PYRD_BRUC2 ;
DR   C0RH28, PYRD_BRUMB ;  Q8YFB1, PYRD_BRUME ;  A5VNQ1, PYRD_BRUO2 ;
DR   B0CJU0, PYRD_BRUSI ;  Q8G2K8, PYRD_BRUSU ;  P57443, PYRD_BUCAI ;
DR   Q8K9I5, PYRD_BUCAP ;  A0K729, PYRD_BURCH ;  B4E8N4, PYRD_BURCJ ;
DR   Q0BFR0, PYRD_BURCM ;  Q39GX5, PYRD_BURL3 ;  A9AJX4, PYRD_BURM1 ;
DR   A3MJ98, PYRD_BURM7 ;  A2S374, PYRD_BURM9 ;  Q62K45, PYRD_BURMA ;
DR   A1V4A5, PYRD_BURMS ;  Q1BWM4, PYRD_BURO1 ;  A3NUS1, PYRD_BURP0 ;
DR   Q3JSS8, PYRD_BURP1 ;  A3N925, PYRD_BURP6 ;  Q63TV1, PYRD_BURPS ;
DR   Q2SVL9, PYRD_BURTA ;  Q874I4, PYRD_CANAL ;  Q6SZS5, PYRD_CANGA ;
DR   B3PIL8, PYRD_CELJU ;  A3PN03, PYRD_CERS1 ;  Q3IZ94, PYRD_CERS4 ;
DR   B9KNA2, PYRD_CERSK ;  Q11M76, PYRD_CHESB ;  A9WDI1, PYRD_CHLAA ;
DR   B9LHC1, PYRD_CHLSY ;  A0M4D0, PYRD_CHRFK ;  Q7NX17, PYRD_CHRVO ;
DR   A8AID4, PYRD_CITK8 ;  A5CS38, PYRD_CLAM3 ;  B0RIK6, PYRD_CLAMS ;
DR   Q480K7, PYRD_COLP3 ;  Q6NH79, PYRD_CORDI ;  Q8FTC6, PYRD_COREF ;
DR   A4QEA4, PYRD_CORGB ;  Q8NQC0, PYRD_CORGL ;  Q9FB59, PYRD_CORST ;
DR   B6J754, PYRD_COXB1 ;  B6J0A5, PYRD_COXB2 ;  A9KCF2, PYRD_COXBN ;
DR   A9NCV1, PYRD_COXBR ;  Q83CY0, PYRD_COXBU ;  B1WUM4, PYRD_CROS5 ;
DR   A7MEW0, PYRD_CROS8 ;  Q1LP27, PYRD_CUPMC ;  Q0KBT4, PYRD_CUPNH ;
DR   Q472J6, PYRD_CUPPJ ;  B3R4T0, PYRD_CUPTR ;  B8HW33, PYRD_CYAP4 ;
DR   P28294, PYRD_CYCAE ;  Q47GW1, PYRD_DECAR ;  C1CX89, PYRD_DEIDV ;
DR   Q1J132, PYRD_DEIGD ;  Q9RX14, PYRD_DEIRA ;  A9BWU2, PYRD_DELAS ;
DR   A5EV79, PYRD_DICNV ;  P32748, PYRD_DROME ;  A7ZK49, PYRD_ECO24 ;
DR   B7UN24, PYRD_ECO27 ;  B7MHP7, PYRD_ECO45 ;  B7LE45, PYRD_ECO55 ;
DR   P0A7E2, PYRD_ECO57 ;  B5YT76, PYRD_ECO5E ;  B7NM29, PYRD_ECO7I ;
DR   B7MS56, PYRD_ECO81 ;  B7M874, PYRD_ECO8A ;  C4ZQ71, PYRD_ECOBW ;
DR   B1X8P9, PYRD_ECODH ;  A7ZYP7, PYRD_ECOHS ;  A1A9L5, PYRD_ECOK1 ;
DR   Q0TJB6, PYRD_ECOL5 ;  Q8FJ91, PYRD_ECOL6 ;  B1IVY7, PYRD_ECOLC ;
DR   P0A7E1, PYRD_ECOLI ;  B7N3A7, PYRD_ECOLU ;  B6I919, PYRD_ECOSE ;
DR   B1LJR7, PYRD_ECOSM ;  Q1RDR9, PYRD_ECOUT ;  C5BD71, PYRD_EDWI9 ;
DR   A4W8V7, PYRD_ENT38 ;  Q75CE1, PYRD_EREGS ;  B2VC84, PYRD_ERWT9 ;
DR   Q2N6N6, PYRD_ERYLH ;  B7LNV5, PYRD_ESCF3 ;  A5FHT2, PYRD_FLAJ1 ;
DR   Q9F1U7, PYRD_FLALU ;  A6H0L5, PYRD_FLAPJ ;  B8F848, PYRD_GLAP5 ;
DR   B7KIU7, PYRD_GLOC7 ;  Q7NC99, PYRD_GLOVI ;  Q7VL56, PYRD_HAEDU ;
DR   Q4QKB5, PYRD_HAEI8 ;  A5UC11, PYRD_HAEIE ;  A5UEP8, PYRD_HAEIG ;
DR   P45477, PYRD_HAEIN ;  Q2SCG9, PYRD_HAHCH ;  A1WTJ3, PYRD_HALHL ;
DR   Q5UYF1, PYRD_HALMA ;  B0R808, PYRD_HALS3 ;  Q9HMK2, PYRD_HALSA ;
DR   C4K4A3, PYRD_HAMD5 ;  Q17WU9, PYRD_HELAH ;  B6JL11, PYRD_HELP2 ;
DR   B5Z6I2, PYRD_HELPG ;  Q1CU70, PYRD_HELPH ;  Q9ZM11, PYRD_HELPJ ;
DR   B2USR9, PYRD_HELPS ;  O25655, PYRD_HELPY ;  A4G7T7, PYRD_HERAR ;
DR   Q02127, PYRD_HUMAN ;  Q5QX65, PYRD_IDILO ;  A6T106, PYRD_JANMA ;
DR   A6WD43, PYRD_KINRD ;  B5XY59, PYRD_KLEP3 ;  A6T739, PYRD_KLEP7 ;
DR   B2GHT4, PYRD_KOCRD ;  Q6V3W9, PYRD_LACK1 ;  Q5X496, PYRD_LEGPA ;
DR   A5ICX8, PYRD_LEGPC ;  Q5ZUH7, PYRD_LEGPH ;  Q5WVN0, PYRD_LEGPL ;
DR   Q6AE78, PYRD_LEIXX ;  B1Y3C1, PYRD_LEPCP ;  Q65TR8, PYRD_MANSM ;
DR   A6VW35, PYRD_MARMS ;  A1TZG0, PYRD_MARN8 ;  B7KZJ5, PYRD_METC4 ;
DR   Q609J2, PYRD_METCA ;  Q1H411, PYRD_METFK ;  B3DX48, PYRD_METI4 ;
DR   B8ID11, PYRD_METNO ;  A2SHQ5, PYRD_METPP ;  O35435, PYRD_MOUSE ;
DR   B1MPD4, PYRD_MYCA9 ;  P65909, PYRD_MYCBO ;  A1KKI2, PYRD_MYCBP ;
DR   C1AQ55, PYRD_MYCBT ;  A4TB97, PYRD_MYCGI ;  P46727, PYRD_MYCLE ;
DR   B2HFZ1, PYRD_MYCMM ;  Q73YS2, PYRD_MYCPA ;  A0QZY9, PYRD_MYCS2 ;
DR   A3Q1C6, PYRD_MYCSJ ;  A1UHW0, PYRD_MYCSK ;  Q1B765, PYRD_MYCSS ;
DR   A5U4G5, PYRD_MYCTA ;  P9WHL0, PYRD_MYCTO ;  P9WHL1, PYRD_MYCTU ;
DR   A0PQW5, PYRD_MYCUA ;  A1TAT2, PYRD_MYCVP ;  Q1D7Y6, PYRD_MYXXD ;
DR   Q3IU78, PYRD_NATPD ;  B9L9P6, PYRD_NAUPA ;  Q5F605, PYRD_NEIG1 ;
DR   A9M3G1, PYRD_NEIM0 ;  Q9JX66, PYRD_NEIMA ;  Q9K1D7, PYRD_NEIMB ;
DR   A1KRQ4, PYRD_NEIMF ;  Q0AIB4, PYRD_NITEC ;  Q82ST3, PYRD_NITEU ;
DR   Q2Y5H8, PYRD_NITMU ;  A6Q2V6, PYRD_NITSB ;  Q5YVM8, PYRD_NOCFA ;
DR   A1SJF2, PYRD_NOCSJ ;  B2IU79, PYRD_NOSP7 ;  Q8YPC6, PYRD_NOSS1 ;
DR   Q2GBY1, PYRD_NOVAD ;  Q7XKC8, PYRD_ORYSJ ;  A1TPZ2, PYRD_PARC0 ;
DR   A7HQ77, PYRD_PARL1 ;  Q7U3U2, PYRD_PARMW ;  B2JKL9, PYRD_PARP8 ;
DR   Q13ZM3, PYRD_PARXL ;  P57858, PYRD_PASMU ;  Q6D456, PYRD_PECAS ;
DR   C6DFC0, PYRD_PECCP ;  Q7N617, PYRD_PHOLL ;  Q6LRA2, PYRD_PHOPR ;
DR   Q08210, PYRD_PLAF7 ;  A4SWU5, PYRD_POLAQ ;  A1VQJ1, PYRD_POLNA ;
DR   B1XV77, PYRD_POLNS ;  Q129L9, PYRD_POLSJ ;  Q5R6X6, PYRD_PONAB ;
DR   B4EVC3, PYRD_PROMH ;  Q7V473, PYRD_PROMM ;  Q48JY0, PYRD_PSE14 ;
DR   Q15UB7, PYRD_PSEA6 ;  A6V325, PYRD_PSEA7 ;  B7UWL8, PYRD_PSEA8 ;
DR   Q02PL5, PYRD_PSEAB ;  Q9HZF8, PYRD_PSEAE ;  B8H8Q4, PYRD_PSECP ;
DR   Q1ICL4, PYRD_PSEE4 ;  Q4KFI7, PYRD_PSEF5 ;  C3K017, PYRD_PSEFS ;
DR   A4XWQ0, PYRD_PSEMY ;  Q3KFC7, PYRD_PSEPF ;  B0KG90, PYRD_PSEPG ;
DR   Q88L40, PYRD_PSEPK ;  B1J5B5, PYRD_PSEPW ;  Q883P1, PYRD_PSESM ;
DR   Q3IGZ1, PYRD_PSET1 ;  Q4ZUM3, PYRD_PSEU2 ;  Q4FS74, PYRD_PSYA2 ;
DR   Q1QBS1, PYRD_PSYCK ;  A1SX25, PYRD_PSYIN ;  A5WDZ3, PYRD_PSYWF ;
DR   Q8XYY7, PYRD_RALN1 ;  Q63707, PYRD_RAT   ;  B3PNN8, PYRD_RHIE6 ;
DR   Q2KCS8, PYRD_RHIEC ;  Q1MLT8, PYRD_RHIJ3 ;  Q98B89, PYRD_RHILO ;
DR   B5ZPH6, PYRD_RHILW ;  Q92S77, PYRD_RHIME ;  B9J901, PYRD_RHIR8 ;
DR   C0ZZY4, PYRD_RHOE4 ;  C1ASU1, PYRD_RHOOB ;  Q2IR55, PYRD_RHOP2 ;
DR   Q07TQ6, PYRD_RHOP5 ;  Q6NBN1, PYRD_RHOPA ;  Q13D13, PYRD_RHOPS ;
DR   B3QEE3, PYRD_RHOPT ;  Q2RX27, PYRD_RHORT ;  B7JXU8, PYRD_RIPO1 ;
DR   A7NLW9, PYRD_ROSCS ;  A5UX75, PYRD_ROSS1 ;  Q21JW9, PYRD_SACD2 ;
DR   B5F1U2, PYRD_SALA4 ;  A8LY18, PYRD_SALAI ;  A9MHU3, PYRD_SALAR ;
DR   Q57QU4, PYRD_SALCH ;  B5FQY8, PYRD_SALDC ;  B5QZE8, PYRD_SALEP ;
DR   B5R8M3, PYRD_SALG2 ;  B4TDY5, PYRD_SALHS ;  B4T1Y8, PYRD_SALNS ;
DR   Q5PGE0, PYRD_SALPA ;  A9N6Y4, PYRD_SALPB ;  C0PVS5, PYRD_SALPC ;
DR   B5BBM2, PYRD_SALPK ;  B4TRW8, PYRD_SALSV ;  Q8Z7S9, PYRD_SALTI ;
DR   A4X619, PYRD_SALTO ;  P25468, PYRD_SALTY ;  P32747, PYRD_SCHPO ;
DR   A8GCK4, PYRD_SERP5 ;  A1S5Z4, PYRD_SHEAM ;  B8E984, PYRD_SHEB2 ;
DR   A3D5B9, PYRD_SHEB5 ;  A6WP30, PYRD_SHEB8 ;  A9L4D0, PYRD_SHEB9 ;
DR   Q12NG2, PYRD_SHEDO ;  Q081J9, PYRD_SHEFN ;  B0TIY0, PYRD_SHEHH ;
DR   A3QDX8, PYRD_SHELP ;  Q8EDZ8, PYRD_SHEON ;  A8H3X8, PYRD_SHEPA ;
DR   A4Y7I2, PYRD_SHEPC ;  B8CPG0, PYRD_SHEPW ;  A0KW50, PYRD_SHESA ;
DR   A8FW61, PYRD_SHESH ;  Q0HJL0, PYRD_SHESM ;  Q0HVV6, PYRD_SHESR ;
DR   A1RJ06, PYRD_SHESW ;  B1KDM8, PYRD_SHEWM ;  B2TUD4, PYRD_SHIB3 ;
DR   Q31YK8, PYRD_SHIBS ;  Q32HW1, PYRD_SHIDS ;  Q0T689, PYRD_SHIF8 ;
DR   Q83RX6, PYRD_SHIFL ;  Q3Z3H6, PYRD_SHISS ;  C3MFT0, PYRD_SINFN ;
DR   A6U5U0, PYRD_SINMW ;  Q2NU82, PYRD_SODGM ;  Q1GVC1, PYRD_SPHAL ;
DR   Q827Q6, PYRD_STRAW ;  Q9KXR7, PYRD_STRCO ;  B1W464, PYRD_STRGG ;
DR   B4STK4, PYRD_STRM5 ;  B2FPI7, PYRD_STRMK ;  A4VM41, PYRD_STUS1 ;
DR   Q30R79, PYRD_SULDN ;  A6Q8G0, PYRD_SULNB ;  Q31RJ7, PYRD_SYNE7 ;
DR   Q2JRL7, PYRD_SYNJA ;  Q2JJF3, PYRD_SYNJB ;  Q5N2Q8, PYRD_SYNP6 ;
DR   P74782, PYRD_SYNY3 ;  C5BKZ2, PYRD_TERTT ;  Q47RF2, PYRD_THEFY ;
DR   Q72KU3, PYRD_THET2 ;  Q5SK69, PYRD_THET8 ;  Q8DLB7, PYRD_THEVB ;
DR   Q3SL21, PYRD_THIDA ;  Q113R9, PYRD_TRIEI ;  Q3MDU0, PYRD_TRIV2 ;
DR   A1WJ81, PYRD_VEREI ;  B7VNK9, PYRD_VIBA3 ;  A7N0L2, PYRD_VIBC1 ;
DR   A5F839, PYRD_VIBC3 ;  Q9KRZ2, PYRD_VIBCH ;  C3LMH4, PYRD_VIBCM ;
DR   Q87PB7, PYRD_VIBPA ;  Q8D9G5, PYRD_VIBVU ;  Q7MKX3, PYRD_VIBVY ;
DR   Q8D370, PYRD_WIGBR ;  Q8PLJ2, PYRD_XANAC ;  Q3BUJ7, PYRD_XANC5 ;
DR   Q4UTX5, PYRD_XANC8 ;  B0RTS3, PYRD_XANCB ;  Q8P9R0, PYRD_XANCP ;
DR   Q2P3M0, PYRD_XANOM ;  B2SLB9, PYRD_XANOP ;  Q5H0N0, PYRD_XANOR ;
DR   A7IBC2, PYRD_XANP2 ;  B2I9T5, PYRD_XYLF2 ;  Q9PAE7, PYRD_XYLFA ;
DR   B0U5I1, PYRD_XYLFM ;  Q87A77, PYRD_XYLFT ;  A1JMP8, PYRD_YERE8 ;
DR   A7FJU2, PYRD_YERP3 ;  Q1CA44, PYRD_YERPA ;  B2JYR8, PYRD_YERPB ;
DR   Q8ZG91, PYRD_YERPE ;  A9R7L2, PYRD_YERPG ;  Q1CGJ0, PYRD_YERPN ;
DR   A4TMZ3, PYRD_YERPP ;  Q66CG4, PYRD_YERPS ;  B1JQS0, PYRD_YERPY ;
//