ID   1.3.98.1
DE   dihydroorotate oxidase (fumarate).
AN   DHOD.
AN   DHODase.
AN   DHOdehase.
AN   dihydoorotic acid dehydrogenase.
AN   dihydroorotate dehydrogenase.
AN   dihydroorotate oxidase.
CA   (S)-dihydroorotate + fumarate = orotate + succinate.
CC   -!- The reaction, which takes place in the cytosol, is the only redox
CC       reaction in the de novo biosynthesis of pyrimidine nucleotides.
CC   -!- Molecular oxygen can replace fumarate in vitro.
CC   -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+)
CC       (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
CC   -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2)
CC       uses quinone as electron acceptor.
CC   -!- Formerly EC 1.3.3.1.
DR   Q7Z895, PYRD1_KLULA;  Q7Z892, PYRD1_LACK1;  Q9YFI6, PYRDA_AERPE;
DR   O66461, PYRDA_AQUAE;  P59626, PYRDA_ENTFA;  Q5FJB5, PYRDA_LACAC;
DR   Q1G864, PYRDA_LACDA;  Q047M3, PYRDA_LACDB;  A8YVZ9, PYRDA_LACH4;
DR   Q74J29, PYRDA_LACJO;  Q9CFC9, PYRDA_LACLA;  Q53ZE5, PYRDA_LACLC;
DR   A2RJT9, PYRDA_LACLM;  Q038Z3, PYRDA_LACP3;  P77887, PYRDA_LACPL;
DR   A5VHS3, PYRDA_LIMRD;  B2G5A3, PYRDA_LIMRJ;  Q03HA9, PYRDA_PEDPA;
DR   Q01YA2, PYRDA_SOLUE;  Q3K2G4, PYRDA_STRA1;  Q8E6L0, PYRDA_STRA3;
DR   Q8E155, PYRDA_STRA5;  C0M8R7, PYRDA_STRE4;  Q99Z28, PYRDA_STRP1;
DR   P0DD66, PYRDA_STRP3;  Q8P0C0, PYRDA_STRP8;  A2RDV3, PYRDA_STRPG;
DR   Q9X9S0, PYRDA_STRPN;  P0DD67, PYRDA_STRPQ;  Q8DQG9, PYRDA_STRR6;
DR   C0MCW6, PYRDA_STRS7;  B9DUS7, PYRDA_STRU0;  B2V726, PYRDA_SULSY;
DR   Q6V3X0, PYRD_NAUCC ;  Q7Z894, PYRD_SACBA ;  Q7Z893, PYRD_SACMI ;
DR   Q7Z891, PYRD_SACPA ;  Q57U83, PYRD_TRYB2 ;  Q4D3W2, PYRD_TRYCC ;
DR   P28272, PYRD_YEAST ;
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