ID   1.3.99.22
DE   Coproporphyrinogen dehydrogenase.
AN   Coproporphyrinogen III oxidase.
AN   Oxygen-independent coproporphyrinogen-III oxidase.
AN   Radical SAM enzyme.
CA   Coproporphyrinogen-III + 2 S-adenosyl-L-methionine = protoporphyrinogen-
CA   IX + 2 CO(2) + 2 L-methionine + 2 5'-deoxyadenosine.
CF   Iron-sulfur.
CC   -!- Differs from EC 1.3.3.3 by using S-adenosyl-L-methionine (AdoMet)
CC       instead of oxygen as oxidant.
CC   -!- Occurs mainly in bacteria, whereas eukaryotes use the oxygen-
CC       dependent oxidase.
CC   -!- The reaction starts by using an electron from the reduced form of the
CC       enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the
CC       radical 5'-deoxyadenosin-5'-yl; this radical initiates attack on the
CC       2-carboxyethyl groups, leading to their conversion into vinyl groups.
CC   -!- This conversion, -.CH-CH(2)-COO- -> -CH=CH(2) + CO(2) + e(-) replaces
CC       the electron initially used.
DR   P33770, HEMF_RHOS4 ;  O67886, HEMN_AQUAE ;  P54304, HEMN_BACSU ;
DR   O31381, HEMN_BRAJA ;  O34162, HEMN_CUPNH ;  P32131, HEMN_ECOLI ;
DR   Q9ZLH0, HEMN_HELPJ ;  O25376, HEMN_HELPY ;  P71756, HEMN_MYCTU ;
DR   Q51676, HEMN_PARDP ;  P95506, HEMN_PASHA ;  P77915, HEMN_PSEAE ;
DR   P95651, HEMN_RHOS5 ;  P0A1E2, HEMN_SALTI ;  P0A1E1, HEMN_SALTY ;
DR   P74132, HEMN_SYNY3 ;  O31067, HEMN_THEVL ;  Q796V8, HEMZ_BACSU ;
DR   P51008, HEMZ_RHOS4 ;
//