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ENZYME entry: EC

Accepted Name
Cypemycin cysteine dehydrogenase (decarboxylating).
Alternative Name(s)
Cypemycin decarboxylase.
Reaction catalysed
Cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys + acceptor <=> C(3,19),S(21)-cypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO(2) + H(2)S + reduced acceptor
  • Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.
  • The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.
  • Formerly EC 1.3.99.n3.
PRIAM enzyme-specific profiles1.3.99.36
KEGG Ligand Database for Enzyme Nomenclature1.3.99.36
IUBMB Enzyme Nomenclature1.3.99.36
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.99.-
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