ID   1.4.1.13
DE   glutamate synthase (NADPH).
AN   glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase.
AN   glutamate synthetase (NADP).
AN   glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP).
AN   glutamine-ketoglutaric aminotransferase.
AN   GOGAT.
AN   L-glutamate synthase.
AN   L-glutamate synthetase.
AN   NADPH-dependent glutamate synthase.
AN   NADPH-glutamate synthase.
CA   2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH.
CC   -!- The reaction takes place in the opposite direction.
CC   -!- The protein is composed of two subunits, alpha and beta.
CC   -!- The alpha subunit is composed of two domains, one hydrolyzing
CC       L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2), the other
CC       combining the produced NH3 with 2-oxoglutarate to produce a second
CC       molecule of L-glutamate (cf. EC 1.4.1.4).
CC   -!- The beta subunit transfers electrons from the cosubstrate.
CC   -!- The NH3 is channeled through a 31 A channel in the active protein.
CC   -!- In the absence of the beta subunit, coupling between the two domains
CC       of the alpha subunit is compromised and some ammonium can be
CC       produced.
CC   -!- In the intact alphabeta complex, ammonia production only takes place
CC       as part of the overall reaction.
CC   -!- Formerly EC 2.6.1.53.
DR   O29309, AGLUS_ARCFU;  Q3Z7F6, AGLUS_DEHM1;  Q58746, AGLUS_METJA;
DR   Q9WYM8, AGLUS_THEMA;  B9KBQ2, AGLUS_THENN;  B1L993, AGLUS_THESQ;
DR   P39812, GLTA_BACSU ;  Q05755, GLTB_AZOBR ;  O34399, GLTB_BACSU ;
DR   P09831, GLTB_ECOLI ;  E1V8I1, GLTB_HALED ;  P96218, GLTB_MYCTU ;
DR   Q05756, GLTD_AZOBR ;  O08340, GLTD_CERSP ;  P09832, GLTD_ECOLI ;
DR   E1V8I0, GLTD_HALED ;  P9WN18, GLTD_MYCTO ;  P9WN19, GLTD_MYCTU ;
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