ID   1.4.1.13
DE   Glutamate synthase (NADPH).
AN   Glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase.
AN   Glutamate synthetase (NADP).
AN   Glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP).
AN   Glutamine-ketoglutaric aminotransferase.
AN   GOGAT.
AN   L-glutamate synthase.
AN   L-glutamate synthetase.
AN   L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing.
AN   NADPH-dependent glutamate synthase.
AN   NADPH-glutamate synthase.
CA   2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH.
CF   FAD; FMN; Iron-sulfur.
CC   -!- The reaction takes place in the opposite direction.
CC   -!- The protein is composed of two subunits, alpha and beta.
CC   -!- The alpha subunit is composed of two domains, one hydrolyzing
CC       L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other
CC       combining the produced NH(3) with 2-oxoglutarate to produce a second
CC       molecule of L-glutamate (cf. EC 1.4.1.4).
CC   -!- The beta subunit transfers electrons to the cosubstrate.
CC   -!- The NH(3) is channeled through a 31 A channel in the active protein.
CC   -!- In the absence of the beta subunit, coupling between the two domains
CC       of the alpha subunit is compromised and some ammonium can be
CC       produced.
CC   -!- In the intact alpha-beta complex, ammonia production only takes place
CC       as part of the overall reaction.
CC   -!- Formerly EC 2.6.1.53.
PR   PROSITE; PDOC00406;
DR   Q9C102, GLT1_SCHPO ;  P39812, GLTA_BACSU ;  Q05755, GLTB_AZOBR ;
DR   O34399, GLTB_BACSU ;  P09831, GLTB_ECOLI ;  Q05756, GLTD_AZOBR ;
DR   P09832, GLTD_ECOLI ;  O08340, GLTD_RHOSH ;  Q58746, GLUS_METJA ;
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