ID   1.4.1.21
DE   aspartate dehydrogenase.
AN   NAD-dependent aspartate dehydrogenase.
AN   NADH2-dependent aspartate dehydrogenase.
AN   NADP(+)-dependent aspartate dehydrogenase.
CA   (1) H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate.
CA   (2) H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate.
CC   -!- The enzyme is strictly specific for L-aspartate as substrate.
CC   -!- It produces the unstable compound 2-iminosuccinate, which, in the
CC       presence of water, hydrolyzes spontaneously to form oxaloacetate.
CC   -!- The enzyme from some archaea and thermophilic bacteria is likely to
CC       transfer 2-iminosuccinate directly to EC 2.5.1.72 preventing its
CC       hydrolysis and enabling the de novo biosynthesis of NAD(+).
DR   Q7WQR6, ASPD1_BORBR;  Q7W1T9, ASPD1_BORPA;  Q7VS76, ASPD1_BORPE;
DR   Q7WLJ8, ASPD2_BORBR;  Q7W850, ASPD2_BORPA;  Q7VX83, ASPD2_BORPE;
DR   Q7WE57, ASPD3_BORBR;  Q6FDH0, ASPD_ACIAD ;  B7GY04, ASPD_ACIB3 ;
DR   B7I8C4, ASPD_ACIB5 ;  B2HVA8, ASPD_ACIBC ;  A3M394, ASPD_ACIBT ;
DR   B0V9I9, ASPD_ACIBY ;  O28440, ASPD_ARCFU ;  Q89FY1, ASPD_BRADU ;
DR   A6X792, ASPD_BRUA4 ;  Q397Y5, ASPD_BURL3 ;  A3MD35, ASPD_BURM7 ;
DR   A2RXI5, ASPD_BURM9 ;  Q62BI3, ASPD_BURMA ;  A1UVC0, ASPD_BURMS ;
DR   A3P4L6, ASPD_BURP0 ;  Q3JFK2, ASPD_BURP1 ;  A3NIZ0, ASPD_BURP6 ;
DR   Q63LV9, ASPD_BURPS ;  Q2T559, ASPD_BURTA ;  Q0K391, ASPD_CUPNH ;
DR   B3R8S4, ASPD_CUPTR ;  A6UVA8, ASPD_META3 ;  Q8TS47, ASPD_METAC ;
DR   Q0W7E0, ASPD_METAR ;  Q46BD6, ASPD_METBF ;  Q12VF1, ASPD_METBU ;
DR   Q2FSK9, ASPD_METHJ ;  Q58325, ASPD_METJA ;  Q8TZ45, ASPD_METKA ;
DR   A4FY69, ASPD_METM5 ;  A9A7M3, ASPD_METM6 ;  A6VK38, ASPD_METM7 ;
DR   Q8PV99, ASPD_METMA ;  Q6LZ92, ASPD_METMP ;  O27054, ASPD_METTH ;
DR   A6USM7, ASPD_METVS ;  A9A1F7, ASPD_NITMS ;  Q126F5, ASPD_POLSJ ;
DR   Q9HYA4, ASPD_PSEAE ;  Q1QBB6, ASPD_PSYCK ;  Q8XRV9, ASPD_RALN1 ;
DR   B2UJ42, ASPD_RALPJ ;  Q5LPG8, ASPD_RUEPO ;  A8GIW3, ASPD_SERP5 ;
DR   Q9X1X6, ASPD_THEMA ;  B1LB32, ASPD_THESQ ;
//