ENZYME entry: EC 1.4.3.13
| Accepted Name |
|---|
| Protein-lysine 6-oxidase.
|
| Alternative Name(s) |
|---|
| Lysyl oxidase. |
| Reaction catalysed |
|---|
| Peptidyl-L-lysyl-peptide + O(2) + H(2)O <=> peptidyl-allysyl-peptide + NH(3) + H(2)O(2) |
| Comment(s) |
|---|
- Also acts on protein 5-hydroxylysine.
- Catalyzes the final known enzymic step required for collagen and
elastin cross-linking in the biosynthesis of normal mature
extracellular matrices.
- These reactions play an important role for the development,
elasticity and extensibility of connective tissue.
- Also active on free amines, such as cadaverine or benzylamine.
|
| Cross-references |
|---|
| PROSITE | PDOC00716 |
| BRENDA | 1.4.3.13 |
| EC2PDB | 1.4.3.13 |
| ExplorEnz | 1.4.3.13 |
| PRIAM enzyme-specific profiles | 1.4.3.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.4.3.13 |
| IUBMB Enzyme Nomenclature | 1.4.3.13 |
| IntEnz | 1.4.3.13 |
| MEDLINE | Find literature relating to 1.4.3.13 |
| MetaCyc | 1.4.3.13 |
| UniProtKB/Swiss-Prot |
|
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