ENZYME entry: EC 1.4.3.21
| Accepted Name |
|---|
| Primary-amine oxidase.
|
| Alternative Name(s) |
|---|
| Amine oxidase. |
| Amine oxidase (copper-containing). |
| Benzylamine oxidase. |
| CAO. |
| Copper amine oxidase. |
| Reaction catalysed |
|---|
| RCH(2)NH(2) + H(2)O + O(2) <=> RCHO + NH(3) + H(2)O(2) |
| Comment(s) |
|---|
- A group of enzymes that oxidize primary monoamines but have little or
no activity toward diamines, such as histamine, or toward secondary
and tertiary amines.
- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone)
and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group
reagents, such as semicarbazide.
- In some mammalian tissues the enzyme also functions as a vascular-
adhesion protein (VAP-1).
- Formerly EC 1.4.3.6.
|
| Cross-references |
|---|
| BRENDA | 1.4.3.21 |
| EC2PDB | 1.4.3.21 |
| ExplorEnz | 1.4.3.21 |
| PRIAM enzyme-specific profiles | 1.4.3.21 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.4.3.21 |
| IUBMB Enzyme Nomenclature | 1.4.3.21 |
| IntEnz | 1.4.3.21 |
| MEDLINE | Find literature relating to 1.4.3.21 |
| MetaCyc | 1.4.3.21 |
| UniProtKB/Swiss-Prot |
| Q07121, AMO1_ARTS1; | Q07123, AMO2_ARTS1; | Q8H1H9, AMO_ARATH; |
| P46883, AMO_ECOLI; | P49250, AMO_ENTAE; | P80695, AMO_KLEOK; |
| P49252, AMO_LENCU; | Q43077, AMO_PEA; | P12807, AMO_PICAN; |
| O75106, AOC2_HUMAN; | Q812C9, AOC2_MOUSE; | Q9TTK6, AOC3_BOVIN; |
| Q16853, AOC3_HUMAN; | O70423, AOC3_MOUSE; | Q5R9I0, AOC3_PONAB; |
| O08590, AOC3_RAT; | Q29437, AOCX_BOVIN; | O46406, AOCY_BOVIN; |
| Q9P7F2, CAO1_SCHPO; | O42890, CAO2_SCHPO; | P46881, PAOX_ARTGO; |
|
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