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ENZYME

ENZYME entry: EC 1.4.3.23

Accepted Name
7-chloro-L-tryptophan oxidase
Reaction catalysed
7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2
Comment(s)
  • This enzyme catalyzes a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes.
  • During catalysis, the bound FAD is reoxidized at the expense of molecular oxygen, producing one molecule of hydrogen peroxide.
  • The enzyme shows significant preference for 7-chloro-L-tryptophan over L-tryptophan.
Cross-references
BRENDA1.4.3.23
EC2PDB1.4.3.23
ExplorEnz1.4.3.23
PRIAM enzyme-specific profiles1.4.3.23
KEGG Ligand Database for Enzyme Nomenclature1.4.3.23
IUBMB Enzyme Nomenclature1.4.3.23
IntEnz1.4.3.23
MEDLINEFind literature relating to 1.4.3.23
MetaCyc1.4.3.23
Rhea expert-curated reactions1.4.3.23
UniProtKB/Swiss-Prot
Q8KHS0, REBO_LENAEQ9S3V1, VIOA_CHRVO

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