ENZYME entry: EC 1.4.7.1
| Accepted Name |
|---|
| Glutamate synthase (ferredoxin).
|
| Alternative Name(s) |
|---|
| Ferredoxin-dependent glutamate synthase. |
| Reaction catalysed |
|---|
| 2 L-glutamate + 2 oxidized ferredoxin <=> L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H(+) |
| Cofactor(s) |
|---|
| FAD; FMN; Iron-sulfur.
|
| Comment(s) |
|---|
- The protein is composed of two domains, one hydrolyzing L-glutamine
to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the
produced NH(3) with 2-oxoglutarate to produce a second molecule of
L-glutamate.
- The NH(3) is channeled through a 24 A channel in the active protein.
- No hydrolysis of glutamine takes place without ferredoxin and
2-oxoglutarate being bound to the protein (5,6).
|
| Cross-references |
|---|
| PROSITE | PDOC00406 |
| BRENDA | 1.4.7.1 |
| EC2PDB | 1.4.7.1 |
| ExplorEnz | 1.4.7.1 |
| PRIAM enzyme-specific profiles | 1.4.7.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.4.7.1 |
| IUBMB Enzyme Nomenclature | 1.4.7.1 |
| IntEnz | 1.4.7.1 |
| MEDLINE | Find literature relating to 1.4.7.1 |
| MetaCyc | 1.4.7.1 |
| UniProtKB/Swiss-Prot |
| Q9ZNZ7, GLTB1_ARATH; | Q9T0P4, GLTB2_ARATH; | Q06434, GLTB_ANTSP; |
| O19906, GLTB_CYACA; | Q08258, GLTB_HORVU; | P23225, GLTB_MAIZE; |
| Q69RJ0, GLTB_ORYSJ; | P51375, GLTB_PORPU; | Q1XDB2, GLTB_PORYE; |
| Q43155, GLTB_SPIOL; | P55037, GLTB_SYNY3; | P55038, GLTS_SYNY3; |
|
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