ID   1.5.1.20
DE   methylenetetrahydrofolate reductase [NAD(P)H].
AN   MTHFR.
CA   (1) (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-
CA   methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH.
CA   (2) (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-
CA   methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH.
CC   -!- A flavoprotein (FAD).
CC   -!- The enzyme catalyzes the reversible conversion of 5,10-
CC       methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an
CC       important role in folate metabolism by regulating the distribution of
CC       one-carbon moieties between cellular methylation reactions and
CC       nucleic acid synthesis.
CC   -!- This enzyme, characterized from Protozoan parasites of the genus
CC       Leishmania, is unique among similar characterized eukaryotic enzymes
CC       in that it lacks the C-terminal allosteric regulatory domain
CC       (allowing it to catalyze a reversible reaction) and uses NADH and
CC       NADPH with equal efficiency under physiological conditions. cf.
CC       EC 1.5.1.53, EC 1.5.1.54, and EC 1.5.7.1.
CC   -!- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.
DR   Q10258, MTHR1_SCHPO;  P46151, MTHR1_YEAST;  O06745, YITJ_BACSU ;
//