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ENZYME entry: EC

Accepted Name
Opine dehydrogenase.
Reaction catalysed
(2S)-2-((1-(R)-carboxyethyl)amino)pentanoate + NAD(+) + H(2)O <=> L-2-aminopentanoic acid + pyruvate + NADH
  • In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine.
  • Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate.
  • In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor.
  • They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine.
  • The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate.
PRIAM enzyme-specific profiles1.5.1.28
KEGG Ligand Database for Enzyme Nomenclature1.5.1.28
IUBMB Enzyme Nomenclature1.5.1.28
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