ID 1.5.1.31 DE berberine reductase. AN (R)-canadine synthase. CA (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH. CC -!- Involved in alkaloid biosynthesis in Corydalis cava to give (R)- CC canadine with the opposite configuration to the precursor of CC berberine (see EC 1.3.3.8). CC -!- Also acts on 7,8-dihydroberberine. //