ID   1.5.1.33
DE   Pteridine reductase.
AN   Pteridine reductase 1.
AN   PTR1.
CA   5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 NADPH.
CC   -!- The enzyme from Leishmania (both amastigote and promastigote forms)
CC       catalyzes the NADPH-dependent reduction of folate and a wide variety
CC       of unconjugated pterins, including biopterin, to their tetrahydro
CC       forms.
CC   -!- It also catalyzes the reduction of 7,8-dihydropterins and 7,8-
CC       dihydrofolate to their tetrahydro forms.
CC   -!- In contrast to EC 1.5.1.3 and EC 1.5.1.34, pteridine reductase will
CC       not catalyze the reduction of the quinonoid form of dihydrobiopterin.
CC   -!- The enzyme is specific for NADPH; no activity has been detected with
CC       NADH.
CC   -!- It also differs from EC 1.5.1.3 in being specific for the B side of
CC       NADPH.
CC   -!- Formerly EC 1.1.1.253.
PR   PROSITE; PDOC00060;
DR   Q01782, PTR1_LEIMA ;  P42556, PTR1_LEITA ;
//