ENZYME entry: EC 1.5.1.46

Accepted Name
Agroclavine dehydrogenase.
Reaction catalysed
Agroclavine + NADP(+) <=> 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH
Comment(s)
  • The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family.
  • The reaction is catalyzed in the opposite direction to that shown.
  • The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione.
Cross-references
BRENDA1.5.1.46
EC2PDB1.5.1.46
ExplorEnz1.5.1.46
PRIAM enzyme-specific profiles1.5.1.46
KEGG Ligand Database for Enzyme Nomenclature1.5.1.46
IUBMB Enzyme Nomenclature1.5.1.46
IntEnz1.5.1.46
MEDLINEFind literature relating to 1.5.1.46
MetaCyc1.5.1.46
UniProtKB/Swiss-Prot
M1WEN5, EASG_CLAP2;  P0CT21, EASG_CLAPU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
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