ID   1.5.1.54
DE   methylenetetrahydrofolate reductase (NADH).
AN   5,10-CH2-H4folate reductase.
AN   5,10-methylenetetrahydrofolate reductase.
AN   5,10-methylenetetrahydrofolate reductase (FADH2).
AN   N(5),10-methylenetetrahydrofolate reductase.
CA   (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-
CA   5,6,7,8-tetrahydrofolate + H(+) + NADH.
CC   -!- A flavoprotein (FAD).
CC   -!- The enzyme, found in plants and some bacteria, catalyzes the
CC       reversible conversion of 5,10-methylenetetrahydrofolate to
CC       5-methyltetrahydrofolate using NADH as the electron donor.
CC   -!- It play an important role in folate metabolism by regulating the
CC       distribution of one-carbon moieties between cellular methylation
CC       reactions and nucleic acid synthesis.
CC   -!- These proteins either contain a C-terminal domain that does not
CC       mediate allosteric regulation (as in plants) or lack this domain
CC       entirely (as in Escherichia coli).
CC   -!- As a result, the plant enzymes are not inhibited by S-adenosyl-L-
CC       methionine, unlike other eukaryotic enzymes, and catalyze a
CC       reversible reaction. cf. EC 1.5.1.53, EC 1.5.1.20, and EC 1.5.7.1.
DR   O67422, METF_AQUAE ;  P57154, METF_BUCAI ;  Q8KA62, METF_BUCAP ;
DR   Q89B13, METF_BUCBP ;  P0AEZ1, METF_ECOLI ;  P45208, METF_HAEIN ;
DR   Q9JZQ3, METF_NEIMB ;  P71319, METF_PECCC ;  P11003, METF_SALTY ;
DR   P0AEZ2, METF_SHIFL ;  G2IQS8, METF_SPHSK ;  O54235, METF_STRLI ;
DR   Q9SE60, MTHR1_ARATH;  Q9SE94, MTHR1_MAIZE;  O80585, MTHR2_ARATH;
DR   Q75HE6, MTHR_ORYSJ ;
//