ENZYME

ENZYME entry: EC 1.5.3.17

Accepted Name

Non-specific polyamine oxidase.

Alternative Name(s)

Polyamine oxidase.

Reaction catalysed

Spermine + O(2) + H(2)O <=> spermidine + 3-aminopropanal + H(2)O(2)
Spermidine + O(2) + H(2)O <=> putrescine + 3-aminopropanal + H(2)O(2)
N(1)-acetylspermine + O(2) + H(2)O <=> spermidine + 3-acetamidopropanal + H(2)O(2)
N(1)-acetylspermidine + O(2) + H(2)O <=> putrescine + 3-acetamidopropanal + H(2)O(2)

Cofactor(s)

FAD.

Comment(s)

The non-specific polyamine oxidases may differ from each other considerably.
The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N(8)-acetylspermidine.
The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine.
The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines.
The specific polyamine oxidases are classified as EC 1.5.3.13, EC 1.5.3.14, EC 1.5.3.15 and EC 1.5.3.16.
Formerly EC 1.5.3.11, EC 1.5.3.n1, EC 1.5.3.n2 and EC 1.5.3.n4.