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ENZYME entry: EC 1.5.4.1

Accepted Name
Pyrimidodiazepine synthase.
Reaction catalysed
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one + glutathione disulfide + H(2)O <=> 6-pyruvoyltetrahydropterin + 2 glutathione
Comment(s)
  • In the reverse direction of reaction, the reduction of 6-pyruvoyl- tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring.
  • The pyrimidodiazepine involved is an acetyldihydro derivative.
  • Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
Cross-references
BRENDA1.5.4.1
EC2PDB1.5.4.1
ExplorEnz1.5.4.1
PRIAM enzyme-specific profiles1.5.4.1
KEGG Ligand Database for Enzyme Nomenclature1.5.4.1
IUBMB Enzyme Nomenclature1.5.4.1
IntEnz1.5.4.1
MEDLINEFind literature relating to 1.5.4.1
MetaCyc1.5.4.1
UniProtKB/Swiss-Prot
Q9VSL3, SEPIA_DROME

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-