ID 1.5.7.1 DE methylenetetrahydrofolate reductase (ferredoxin). AN 5,10-methylenetetrahydrofolate reductase. CA (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] CA = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe- CA 2S]-[ferredoxin]. CC -!- The enzyme from Clostridium formicoaceticum catalyzes the reduction CC of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with CC 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or CC FADH2 with 5,10-methylenetetrahydrofolate. CC -!- However, unlike EC 1.5.1.20, EC 1.5.1.53, or EC 1.5.1.24, there is no CC activity with either NADH or NADP(+). //