ID   1.5.7.3
DE   N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin).
CA   (1) H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] =
CA   formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine.
CA   (2) H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine = formaldehyde +
CA   glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin].
CC   -!- This bacterial enzyme is involved in degradation of glycine betaine.
CC   -!- The enzyme contains non-covalently bound FAD and NAD(P) cofactors,
CC       and catalyzes the demethylation of both N,N-dimethylglycine and
CC       sarcosine, releasing formaldehyde and forming glycine as the final
CC       product.
CC   -!- The enzyme can utilize both NAD(+) and NADP(+), but the catalytic
CC       efficiency with NAD(+) is ~5-fold higher.
CC   -!- The native electron acceptor of the enzyme is a membrane-bound
CC       clostridial-type ferredoxin, which transfers the electrons to an
CC       electron-transfer flavoprotein (ETF).
DR   Q1QYW1, DDHC_CHRSD ;
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