ENZYME entry: EC 1.6.3.1

Accepted Name
NAD(P)H oxidase (H(2)O(2)-forming).
Alternative Name(s)
Dual oxidase.
NAD(P)H oxidase.
ThOX.
THOX2.
Thyroid NADPH oxidase.
Thyroid oxidase.
Thyroid oxidase 2.
Reaction catalysed
NAD(P)H + O(2) <=> NAD(P)(+) + H(2)O(2)
Cofactor(s)
Ca(2+); FAD; Heme.
Comment(s)
  • When calcium is present, this transmembrane glycoprotein generates H(2)O(2) by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen.
  • The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups.
  • This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H(2)O(2) for the thyroid peroxidase-catalyzed biosynthesis of thyroid hormones.
Cross-references
PROSITEPDOC00394
BRENDA1.6.3.1
EC2PDB1.6.3.1
ExplorEnz1.6.3.1
PRIAM enzyme-specific profiles1.6.3.1
KEGG Ligand Database for Enzyme Nomenclature1.6.3.1
IUBMB Enzyme Nomenclature1.6.3.1
IntEnz1.6.3.1
MEDLINEFind literature relating to 1.6.3.1
MetaCyc1.6.3.1
UniProtKB/Swiss-Prot
O61213, DUOX1_CAEEL;  Q9MZF4, DUOX1_CANLF;  Q9NRD9, DUOX1_HUMAN;  
Q8HZK3, DUOX1_PIG;  Q8CIY2, DUOX1_RAT;  Q9NRD8, DUOX2_HUMAN;  
Q8HZK2, DUOX2_PIG;  Q9ES45, DUOX2_RAT;  Q9VQH2, DUOX_DROME;  

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