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ENZYME entry: EC 1.6.3.5

Accepted Name
Renalase.
Alternative Name(s)
Alpha-NAD(P)H oxidase/anomerase.
Reaction catalysed
  • 1,2-dihydro-beta-NAD(P) + H(+) + O(2) <=> beta-NAD(P)(+) + H(2)O(2)
  • 1,6-dihydro-beta-NAD(P) + H(+) + O(2) <=> beta-NAD(P)(+) + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+).
  • These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
Cross-references
BRENDA1.6.3.5
EC2PDB1.6.3.5
ExplorEnz1.6.3.5
PRIAM enzyme-specific profiles1.6.3.5
KEGG Ligand Database for Enzyme Nomenclature1.6.3.5
IUBMB Enzyme Nomenclature1.6.3.5
IntEnz1.6.3.5
MEDLINEFind literature relating to 1.6.3.5
MetaCyc1.6.3.5
UniProtKB/Swiss-Prot
Q5VYX0, RNLS_HUMAN;  A7RDN6, RNLS_MOUSE;  Q48MT7, RNLS_PSE14;  
Q888A4, RNLS_PSESM;  Q5U2W9, RNLS_RAT;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-