ENZYME entry: EC 1.6.5.2

Accepted Name
NAD(P)H dehydrogenase (quinone).
Alternative Name(s)
Azoreductase.
Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone).
Diaphorase.
DT-diaphorase.
Flavoprotein NAD(P)H-quinone reductase.
Menadione oxidoreductase.
Menadione reductase.
NAD(P)H dehydrogenase.
NAD(P)H menadione reductase.
NAD(P)H(2) dehydrogenase (quinone).
NAD(P)H-quinone dehydrogenase.
NAD(P)H-quinone oxidoreductase.
NAD(P)H: menadione oxidoreductase.
NAD(P)H:(quinone-acceptor)oxidoreductase.
NADH-menadione reductase.
Naphthoquinone reductase.
p-benzoquinone reductase.
Phylloquinone reductase.
Quinone reductase.
Reduced NAD(P)H dehydrogenase.
Reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase.
Viologen accepting pyridine nucleotide oxidoreductase.
Vitamin K reductase.
Vitamin-K reductase.
Reaction catalysed
NAD(P)H + a quinone <=> NAD(P)(+) + a hydroquinone
Cofactor(s)
FAD.
Comment(s)
  • The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone.
  • The animal, but not the plant, form of the enzyme is inhibited by dicoumarol.
  • Formerly EC 1.6.99.2.
Cross-references
BRENDA1.6.5.2
EC2PDB1.6.5.2
ExplorEnz1.6.5.2
PRIAM enzyme-specific profiles1.6.5.2
KEGG Ligand Database for Enzyme Nomenclature1.6.5.2
IUBMB Enzyme Nomenclature1.6.5.2
IntEnz1.6.5.2
MEDLINEFind literature relating to 1.6.5.2
MetaCyc1.6.5.2
UniProtKB/Swiss-Prot
A8ALQ5, KEFF_CITK8;  A7ZHD9, KEFF_ECO24;  B7UI92, KEFF_ECO27;  
B7MAG9, KEFF_ECO45;  B7L4G9, KEFF_ECO55;  Q8XA24, KEFF_ECO57;  
B5YZ82, KEFF_ECO5E;  B7NHF0, KEFF_ECO7I;  B7MNQ3, KEFF_ECO81;  
B7M0E3, KEFF_ECO8A;  C4ZPX2, KEFF_ECOBW;  B1XC47, KEFF_ECODH;  
A7ZVZ8, KEFF_ECOHS;  A1A795, KEFF_ECOK1;  Q0TLU3, KEFF_ECOL5;  
P0A755, KEFF_ECOL6;  B1IRD0, KEFF_ECOLC;  P0A754, KEFF_ECOLI;  
B7N7S1, KEFF_ECOLU;  B6HYZ7, KEFF_ECOSE;  B1LFY0, KEFF_ECOSM;  
Q1RGF2, KEFF_ECOUT;  A4W6F2, KEFF_ENT38;  Q9X755, KEFF_ENTAE;  
B7LVT7, KEFF_ESCF3;  B5Y1Z9, KEFF_KLEP3;  B5F766, KEFF_SALA4;  
A9MQG7, KEFF_SALAR;  Q57TH5, KEFF_SALCH;  B5FI28, KEFF_SALDC;  
B5R1S3, KEFF_SALEP;  B5RGB7, KEFF_SALG2;  B4TII5, KEFF_SALHS;  
B4T6L1, KEFF_SALNS;  C0Q4M9, KEFF_SALPC;  B4TWT0, KEFF_SALSV;  
Q8Z9K1, KEFF_SALTI;  Q8ZRW3, KEFF_SALTY;  B2U254, KEFF_SHIB3;  
Q326I7, KEFF_SHIBS;  Q32K50, KEFF_SHIDS;  Q0T8E9, KEFF_SHIF8;  
Q83SQ4, KEFF_SHIFL;  Q3Z5W3, KEFF_SHISS;  A8AQP1, KEFG_CITK8;  
A7ME22, KEFG_CROS8;  A7ZSM7, KEFG_ECO24;  B7UK62, KEFG_ECO27;  
B7MCW7, KEFG_ECO45;  B7L4M8, KEFG_ECO55;  P0A758, KEFG_ECO57;  
B5YTQ8, KEFG_ECO5E;  B7NMB9, KEFG_ECO7I;  B7N1D3, KEFG_ECO81;  
B7M1Q3, KEFG_ECO8A;  C4ZUK7, KEFG_ECOBW;  B1X6K1, KEFG_ECODH;  
A8A5F9, KEFG_ECOHS;  A1AGN7, KEFG_ECOK1;  Q0TCA9, KEFG_ECOL5;  
P0A757, KEFG_ECOL6;  B1IPB3, KEFG_ECOLC;  P0A756, KEFG_ECOLI;  
B7NDW0, KEFG_ECOLU;  B6I2R0, KEFG_ECOSE;  Q1R5T1, KEFG_ECOUT;  
A4WFE5, KEFG_ENT38;  B2VK48, KEFG_ERWT9;  B7LS58, KEFG_ESCF3;  
Q6CZU4, KEFG_PECAS;  C6DG98, KEFG_PECCP;  B5F8H0, KEFG_SALA4;  
Q57J14, KEFG_SALCH;  B5FJN2, KEFG_SALDC;  B5R2A9, KEFG_SALEP;  
B5RGZ7, KEFG_SALG2;  B4TKN3, KEFG_SALHS;  B4SUV8, KEFG_SALNS;  
Q5PL20, KEFG_SALPA;  A9MT18, KEFG_SALPB;  C0Q0D4, KEFG_SALPC;  
B5BH04, KEFG_SALPK;  B4TXG0, KEFG_SALSV;  P65511, KEFG_SALTI;  
P65510, KEFG_SALTY;  A8GKL4, KEFG_SERP5;  Q32B14, KEFG_SHIDS;  
Q0SZW5, KEFG_SHIF8;  Q83PX9, KEFG_SHIFL;  A1JS77, KEFG_YERE8;  
A7FNQ1, KEFG_YERP3;  Q1C2S8, KEFG_YERPA;  B2K5P7, KEFG_YERPB;  
Q8ZJC5, KEFG_YERPE;  A9R474, KEFG_YERPG;  Q1CCS6, KEFG_YERPN;  
A4TGX4, KEFG_YERPP;  Q664Q4, KEFG_YERPS;  B1JIU3, KEFG_YERPY;  
P9WHH6, LPDA_MYCTO;  P9WHH7, LPDA_MYCTU;  Q8CHK7, NQO1_CAVPO;  
P15559, NQO1_HUMAN;  Q64669, NQO1_MOUSE;  Q5RD31, NQO1_PONAB;  
P05982, NQO1_RAT;  Q92PU3, NQOR1_RHIME;  Q930L2, NQOR2_RHIME;  
Q92Y27, NQOR3_RHIME;  A5G020, NQOR_ACICJ;  B9M9X5, NQOR_ACIET;  
B7J4K3, NQOR_ACIF2;  B5EMU4, NQOR_ACIF5;  B9JEB9, NQOR_AGRRK;  
P58795, NQOR_AGRT5;  Q0A961, NQOR_ALKEH;  O29904, NQOR_ARCFU;  
Q5P5L5, NQOR_AROAE;  A8HRS7, NQOR_AZOC5;  A1K9S9, NQOR_AZOSB;  
C1DFX8, NQOR_AZOVD;  B2IEF8, NQOR_BEII9;  Q89D74, NQOR_BRADU;  
A5ECG6, NQOR_BRASB;  A4Z0W6, NQOR_BRASO;  B2S5Q9, NQOR_BRUA1;  
Q2YQ23, NQOR_BRUA2;  Q57D82, NQOR_BRUAB;  A9M560, NQOR_BRUC2;  
C0RJ23, NQOR_BRUMB;  Q8YH68, NQOR_BRUME;  A5VQI8, NQOR_BRUO2;  
B0CGJ9, NQOR_BRUSI;  Q8G0P0, NQOR_BRUSU;  B1Z3G9, NQOR_BURA4;  
Q1BIC1, NQOR_BURCA;  B1KBY1, NQOR_BURCC;  A0KCF0, NQOR_BURCH;  
B4EPK7, NQOR_BURCJ;  Q0B2K2, NQOR_BURCM;  A9AT43, NQOR_BURM1;  
B2JML0, NQOR_BURP8;  B2T8L2, NQOR_BURPP;  Q39LI8, NQOR_BURS3;  
A4JT91, NQOR_BURVG;  B8H1H5, NQOR_CAUCN;  Q9AA17, NQOR_CAUCR;  
B0SZC3, NQOR_CAUSK;  Q11IN8, NQOR_CHESB;  Q1QYF4, NQOR_CHRSD;  
A8AI59, NQOR_CITK8;  Q9RYU4, NQOR_DEIRA;  C4XGC2, NQOR_DESMR;  
A7ZKA9, NQOR_ECO24;  B7UNY7, NQOR_ECO27;  B7MIE9, NQOR_ECO45;  
B7LFB3, NQOR_ECO55;  Q8X4B4, NQOR_ECO57;  B5YU47, NQOR_ECO5E;  
B7NLC1, NQOR_ECO7I;  B7M8Y8, NQOR_ECO8A;  C4ZQD2, NQOR_ECOBW;  
B1X9C5, NQOR_ECODH;  A7ZYV7, NQOR_ECOHS;  A1A9Q9, NQOR_ECOK1;  
Q0TJ63, NQOR_ECOL5;  P0A8G7, NQOR_ECOL6;  B1IV93, NQOR_ECOLC;  
P0A8G6, NQOR_ECOLI;  B7N3F9, NQOR_ECOLU;  B6I980, NQOR_ECOSE;  
B1LJ00, NQOR_ECOSM;  Q1RDL3, NQOR_ECOUT;  A4W916, NQOR_ENT38;  
B7LP27, NQOR_ESCF3;  B9M4V3, NQOR_GEODF;  B3E9H6, NQOR_GEOLS;  
Q39XL1, NQOR_GEOMG;  Q74F05, NQOR_GEOSL;  A5G4G8, NQOR_GEOUR;  
A9HFY5, NQOR_GLUDA;  A1WUN2, NQOR_HALHL;  B5XXP0, NQOR_KLEP3;  
A1U5D9, NQOR_MARAV;  A6W2V6, NQOR_MARMS;  P58796, NQOR_METAC;  
Q46B88, NQOR_METBF;  B7KQ28, NQOR_METC4;  A9VY95, NQOR_METEP;  
Q8PUV4, NQOR_METMA;  B1ZJX9, NQOR_METPB;  B1LY35, NQOR_METRJ;  
B0UFU2, NQOR_METS4;  B8EMJ5, NQOR_METSB;  Q3J8H5, NQOR_NITOC;  
Q3SU01, NQOR_NITWN;  A6X0U8, NQOR_OCHA4;  B6JBZ6, NQOR_OLICO;  
A1BAT3, NQOR_PARDP;  A7HVA3, NQOR_PARL1;  Q7N5I5, NQOR_PHOLL;  
Q9I509, NQOR_PSEAE;  Q1LFW3, NQOR_RALME;  Q1MHW6, NQOR_RHIL3;  
C3MCH2, NQOR_RHISN;  B6ITN1, NQOR_RHOCS;  Q2IRH1, NQOR_RHOP2;  
Q07TR7, NQOR_RHOP5;  Q6NBB9, NQOR_RHOPA;  Q21B81, NQOR_RHOPB;  
Q130C0, NQOR_RHOPS;  B3QFA1, NQOR_RHOPT;  Q2RXG7, NQOR_RHORT;  
B5F202, NQOR_SALA4;  A9MH45, NQOR_SALAR;  B5FR47, NQOR_SALDC;  
B5R056, NQOR_SALEP;  B5R6H0, NQOR_SALG2;  B4TEP2, NQOR_SALHS;  
B4T2V2, NQOR_SALNS;  Q5PG91, NQOR_SALPA;  A9N6R4, NQOR_SALPB;  
C0Q886, NQOR_SALPC;  B5BBG6, NQOR_SALPK;  B4TSN0, NQOR_SALSV;  
Q8Z7N9, NQOR_SALTI;  Q8ZQ40, NQOR_SALTY;  A8GCS6, NQOR_SERP5;  
Q32HQ6, NQOR_SHIDS;  Q0T630, NQOR_SHIF8;  P0A8G8, NQOR_SHIFL;  
Q3Z3B7, NQOR_SHISS;  A5VA47, NQOR_SPHWW;  Q2LPM7, NQOR_SYNAS;  
A0LNQ8, NQOR_SYNFM;  Q31GW8, NQOR_THICR;  C4L7R5, NQOR_TOLAT;  
A7IE31, NQOR_XANP2;  A1JMU2, NQOR_YERE8;  A7FJ02, NQOR_YERP3;  
Q1C8L9, NQOR_YERPA;  B2K198, NQOR_YERPB;  Q8ZF61, NQOR_YERPE;  
A9R7R8, NQOR_YERPG;  Q1CHD6, NQOR_YERPN;  A4TK49, NQOR_YERPP;  
Q66BP3, NQOR_YERPS;  B1JNA9, NQOR_YERPY;  Q9XBR5, NQOR_ZYMMO;  
Q941Z0, NQR1_ORYSJ;  Q941Y8, NQR2_ORYSJ;  Q9LK88, NQR_ARATH;  
Q8H9D2, NQR_SOLTU;  C1I202, PNPB_PSEWB;  P39315, QOR2_ECOLI;  

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