ENZYME entry: EC 1.6.99.3

Accepted Name
NADH dehydrogenase.
Alternative Name(s)
Beta-NADH dehydrogenase dinucleotide.
Cytochrome c reductase.
Diaphorase.
Dihydrocodehydrogenase I dehydrogenase.
Dihydronicotinamide adenine dinucleotide dehydrogenase.
Diphosphopyrinase.
DPNH diaphorase.
NADH diaphorase.
NADH hydrogenase.
NADH oxidoreductase.
NADH-menadione oxidoreductase.
NADH:cytochrome c oxidoreductase.
Reduced diphosphopyridine nucleotide diaphorase.
Type 1 dehydrogenase.
Type I dehydrogenase.
Reaction catalysed
NADH + acceptor <=> NAD(+) + reduced acceptor
Cofactor(s)
Flavoprotein; Iron-sulfur.
Comment(s)
  • After preparations have been subjected to certain treatments cytochrome c may act as acceptor.
  • Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment.
  • Present in a mitochondrial complex as EC 1.6.5.3.
  • Formerly EC 1.6.2.1.
Cross-references
PROSITEPDOC00496
BRENDA1.6.99.3
EC2PDB1.6.99.3
ExplorEnz1.6.99.3
PRIAM enzyme-specific profiles1.6.99.3
KEGG Ligand Database for Enzyme Nomenclature1.6.99.3
IUBMB Enzyme Nomenclature1.6.99.3
IntEnz1.6.99.3
MEDLINEFind literature relating to 1.6.99.3
MetaCyc1.6.99.3
UniProtKB/Swiss-Prot
P42974, DHNA_BACSU;  P26829, DHNA_BACYN;  P00393, DHNA_ECOLI;  
P44856, DHNA_HAEIN;  P37061, NAOX_ENTFA;  A2RIB7, NAOX_LACLM;  
Q58065, NAOX_METJA;  Q49408, NAOX_MYCGE;  P75389, NAOX_MYCPN;  
Q5XC60, NAOX_STRP6;  Q42599, NDS8A_ARATH;  Q9FX83, NDS8B_ARATH;  
Q37373, NDUS1_ACACA;  Q9FGI6, NDUS1_ARATH;  P15690, NDUS1_BOVIN;  
Q2LCP5, NDUS1_DICCI;  Q34312, NDUS1_DICDI;  Q94511, NDUS1_DROME;  
Q0MQG1, NDUS1_GORGO;  P28331, NDUS1_HUMAN;  Q4R6K9, NDUS1_MACFA;  
P86203, NDUS1_MESAU;  Q91VD9, NDUS1_MOUSE;  P24918, NDUS1_NEUCR;  
Q0MQG2, NDUS1_PANTR;  P0CB67, NDUS1_PONAB;  P0CB68, NDUS1_PONPY;  
Q66HF1, NDUS1_RAT;  O21241, NDUS1_RECAM;  Q43644, NDUS1_SOLTU;  
Q37384, NDUS2_ACACA;  P93306, NDUS2_ARATH;  P17694, NDUS2_BOVIN;  
Q93873, NDUS2_CAEEL;  Q9TAJ7, NDUS2_CAFRO;  Q2LCR5, NDUS2_DICCI;  
Q23883, NDUS2_DICDI;  Q0MQG4, NDUS2_GORGO;  O75306, NDUS2_HUMAN;  
P86250, NDUS2_MESAU;  Q91WD5, NDUS2_MOUSE;  Q9TC96, NDUS2_NEPOL;  
P22142, NDUS2_NEUCR;  Q36450, NDUS2_NICSY;  Q5DUX5, NDUS2_NYCOV;  
Q0MQG5, NDUS2_PANTR;  P15689, NDUS2_PARTE;  Q0MQG3, NDUS2_PONPY;  
Q37619, NDUS2_PROWI;  Q37720, NDUS2_PYLLI;  Q641Y2, NDUS2_RAT;  
O21270, NDUS2_RECAM;  P80264, NDUS2_SOLTU;  Q37383, NDUS3_ACACA;  
Q95748, NDUS3_ARATH;  Q33994, NDUS3_BETTR;  Q37787, NDUS3_BETVU;  
P23709, NDUS3_BOVIN;  Q00673, NDUS3_CANMA;  Q2LCR4, NDUS3_DICCI;  
P22237, NDUS3_DICDI;  Q0MQG7, NDUS3_GORGO;  O75489, NDUS3_HUMAN;  
P34944, NDUS3_MARPO;  P86217, NDUS3_MESAU;  Q9DCT2, NDUS3_MOUSE;  
P23710, NDUS3_NEUCR;  Q35322, NDUS3_ORYSJ;  Q0MQG8, NDUS3_PANTR;  
P15601, NDUS3_PARPR;  P15600, NDUS3_PARTE;  Q34011, NDUS3_PATWE;  
Q0MQG6, NDUS3_PONPY;  Q37622, NDUS3_PROWI;  O21271, NDUS3_RECAM;  
P80261, NDUS3_SOLTU;  Q42577, NDUS7_ARATH;  P42026, NDUS7_BOVIN;  
P42027, NDUS7_BRAOL;  A8XFG2, NDUS7_CAEBR;  Q94360, NDUS7_CAEEL;  
Q0MQH9, NDUS7_GORGO;  O75251, NDUS7_HUMAN;  Q9DC70, NDUS7_MOUSE;  
O47950, NDUS7_NEUCR;  Q0MQI0, NDUS7_PANTR;  P0CB83, NDUS7_PONAB;  
P0CB84, NDUS7_PONPY;  Q43844, NDUS7_SOLTU;  Q26783, NDUS7_TRYBB;  
P42028, NDUS8_BOVIN;  Q22619, NDUS8_CAEEL;  Q0MQI2, NDUS8_GORGO;  
O00217, NDUS8_HUMAN;  Q60HE3, NDUS8_MACFA;  Q8K3J1, NDUS8_MOUSE;  
Q12644, NDUS8_NEUCR;  Q0MQI3, NDUS8_PANTR;  P0CB97, NDUS8_PONAB;  
P0CB98, NDUS8_PONPY;  P80269, NDUS8_SOLTU;  O24143, NDUS8_TOBAC;  
Q9FNN5, NDUV1_ARATH;  Q92406, NDUV1_ASPNG;  P25708, NDUV1_BOVIN;  
Q54I90, NDUV1_DICDI;  Q0MQI5, NDUV1_GORGO;  P49821, NDUV1_HUMAN;  
Q8HXQ9, NDUV1_MACFA;  Q91YT0, NDUV1_MOUSE;  P24917, NDUV1_NEUCR;  
Q0MQI6, NDUV1_PANTR;  Q0MQI4, NDUV1_PONPY;  O22769, NDUV2_ARATH;  
P04394, NDUV2_BOVIN;  Q20719, NDUV2_CAEEL;  P49820, NDUV2_CANFA;  
Q54F10, NDUV2_DICDI;  Q0MQI8, NDUV2_GORGO;  P19404, NDUV2_HUMAN;  
Q9D6J6, NDUV2_MOUSE;  P40915, NDUV2_NEUCR;  Q0MQI9, NDUV2_PANTR;  
Q0MQI7, NDUV2_PONPY;  P19234, NDUV2_RAT;  Q60049, NOX_THET8;  
P25710, NUJM_NEUCR;  P80268, NUO2_SOLTU;  P80263, NUO3_SOLTU;  
P80262, NUO5_SOLTU;  P80729, NUO6_SOLTU;  P80730, NUO7_SOLTU;  
P80731, NUO8_SOLTU;  P42116, NURM_NEUCR;  Q02854, NUXM_NEUCR;  
P19968, NUZM_NEUCR;  

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