ENZYME entry: EC 1.8.3.5

Accepted Name
Prenylcysteine oxidase.
Alternative Name(s)
Prenylcysteine lyase.
Reaction catalysed
An S-prenyl-L-cysteine + O(2) + H(2)O <=> a prenal + L-cysteine + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine.
  • N-acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates.
  • May represent the final step in the degradation of prenylated proteins in mammalian tissues.
  • Originally thought to be a simple lyase, EC 4.4.1.18.
Cross-references
BRENDA1.8.3.5
EC2PDB1.8.3.5
ExplorEnz1.8.3.5
PRIAM enzyme-specific profiles1.8.3.5
KEGG Ligand Database for Enzyme Nomenclature1.8.3.5
IUBMB Enzyme Nomenclature1.8.3.5
IntEnz1.8.3.5
MEDLINEFind literature relating to 1.8.3.5
MetaCyc1.8.3.5
UniProtKB/Swiss-Prot
Q9UHG3, PCYOX_HUMAN;  Q95KC9, PCYOX_MACFA;  Q9CQF9, PCYOX_MOUSE;  
Q5R748, PCYOX_PONAB;  Q99ML5, PCYOX_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.3.-
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