ID 1.8.4.12 DE peptide-methionine (R)-S-oxide reductase. AN methionine S-oxide reductase. AN methionine S-oxide reductase (R-form oxidizing). AN methionine sulfoxide reductase. AN methionine sulfoxide reductase B. AN selenoprotein R. CA [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]- CA dithiol + L-methionyl-(R)-S-oxide-[protein]. CC -!- The reaction occurs in the reverse direction to that shown above. CC -!- Exhibits high specificity for reduction of the R-form of methionine CC S-oxide, with higher activity being observed with L-methionine CC S-oxide than with D-methionine S-oxide. CC -!- While both free and protein-bound methionine (R)-S-oxide act as CC substrates, the activity with the peptide-bound form is far greater. CC -!- Plays a role in preventing oxidative-stress damage caused by reactive CC oxygen species by reducing the oxidized form of methionine back to CC methionine and thereby reactivating peptides that had been damaged. CC -!- The reaction proceeds via a sulfenic-acid intermediate. CC -!- For MsrB2 and MsrB3, thioredoxin is a poor reducing agent but CC thionein works well. DR P0A3Q9, MSAB1_STRPN; P0A3R0, MSAB1_STRR6; P65443, MSAB2_STRPN; DR P65444, MSAB2_STRR6; Q802G6, MSB1A_DANRE; Q9AL99, MSRAB_AGGAC; DR Q93KF3, MSRAB_CAMFE; P86890, MSRAB_ENTFL; P45213, MSRAB_HAEIN; DR Q9ZMK8, MSRAB_HELPJ; O25011, MSRAB_HELPY; P14930, MSRAB_NEIGO; DR Q9JWM8, MSRAB_NEIMA; Q9K1N8, MSRAB_NEIMB; Q9LAM9, MSRAB_STRGC; DR Q99YT1, MSRAB_STRP1; P0DC40, MSRAB_STRP3; Q5XAX5, MSRAB_STRP6; DR Q8P046, MSRAB_STRP8; P0DC41, MSRAB_STRPQ; O83641, MSRAB_TREPA; DR Q9KLX6, MSRAB_VIBCH; Q9C8M2, MSRB1_ARATH; Q3MHL9, MSRB1_BOVIN; DR Q9NZV6, MSRB1_HUMAN; Q9JLC3, MSRB1_MOUSE; Q0DC89, MSRB1_ORYSJ; DR A1E952, MSRB1_PIG ; Q5R869, MSRB1_PONAB; Q52KJ8, MSRB1_RAT ; DR Q92RA4, MSRB1_RHIME; Q9C5C8, MSRB2_ARATH; Q6NW52, MSRB2_DANRE; DR Q9Y3D2, MSRB2_HUMAN; Q78J03, MSRB2_MOUSE; Q4FZX5, MSRB2_RAT ; DR Q92Y46, MSRB2_RHIME; Q9M0Z6, MSRB3_ARATH; Q8IXL7, MSRB3_HUMAN; DR Q8BU85, MSRB3_MOUSE; Q6AUK5, MSRB3_ORYSJ; Q5R930, MSRB3_PONAB; DR Q9M0Z5, MSRB4_ARATH; Q9ZS91, MSRB5_ARATH; Q10L32, MSRB5_ORYSJ; DR Q8GWF4, MSRB6_ARATH; Q8VY86, MSRB7_ARATH; O49707, MSRB8_ARATH; DR Q84JT6, MSRB9_ARATH; B0BYW4, MSRB_ACAM1 ; Q6FAL8, MSRB_ACIAD ; DR B7H3X2, MSRB_ACIB3 ; B7I415, MSRB_ACIB5 ; B2HYT2, MSRB_ACIBC ; DR B0VR86, MSRB_ACIBS ; A3M4Q3, MSRB_ACIBT ; B0VC45, MSRB_ACIBY ; DR Q8UGX7, MSRB_AGRFC ; Q0A706, MSRB_ALKEH ; B4RUW0, MSRB_ALTMD ; DR C1DRM1, MSRB_AZOVD ; Q65ID2, MSRB_BACLD ; A8FEA3, MSRB_BACP2 ; DR P54155, MSRB_BACSU ; A7Z5S1, MSRB_BACVZ ; Q89EM9, MSRB_BRADU ; DR P65447, MSRB_BRUME ; P65448, MSRB_BRUSU ; B1YRN6, MSRB_BURA4 ; DR A0K833, MSRB_BURCH ; B4EBK9, MSRB_BURCJ ; Q0BEH0, MSRB_BURCM ; DR Q39FG2, MSRB_BURL3 ; A9AJS6, MSRB_BURM1 ; A2SBI6, MSRB_BURM9 ; DR Q62JM6, MSRB_BURMA ; A1V4U8, MSRB_BURMS ; B1JTT6, MSRB_BURO0 ; DR Q1BH71, MSRB_BURO1 ; Q3JRF0, MSRB_BURP1 ; Q63V23, MSRB_BURPS ; DR Q2SWN9, MSRB_BURTA ; A4JEZ1, MSRB_BURVG ; P34436, MSRB_CAEEL ; DR Q9A6B1, MSRB_CAUVC ; B8GY23, MSRB_CAUVN ; B3PK10, MSRB_CELJU ; DR Q1QXV3, MSRB_CHRSD ; Q97IU0, MSRB_CLOAB ; Q0TPZ6, MSRB_CLOP1 ; DR Q8XJZ6, MSRB_CLOPE ; Q0SSL4, MSRB_CLOPS ; Q47EU6, MSRB_DECAR ; DR Q9RUK6, MSRB_DEIRA ; Q72EK2, MSRB_DESVH ; Q8INK9, MSRB_DROME ; DR A7ZMP8, MSRB_ECO24 ; B7USF8, MSRB_ECO27 ; B7MAY9, MSRB_ECO45 ; DR B7L6Q3, MSRB_ECO55 ; P0A748, MSRB_ECO57 ; B5YQ71, MSRB_ECO5E ; DR B7NSZ8, MSRB_ECO7I ; B7MVQ9, MSRB_ECO81 ; B7M1J2, MSRB_ECO8A ; DR C4ZZD4, MSRB_ECOBW ; B1XGN8, MSRB_ECODH ; A8A0X0, MSRB_ECOHS ; DR Q0TH50, MSRB_ECOL5 ; P0A747, MSRB_ECOL6 ; B1IPF3, MSRB_ECOLC ; DR P0A746, MSRB_ECOLI ; B7N5B4, MSRB_ECOLU ; B6IBJ9, MSRB_ECOSE ; DR B1LDV3, MSRB_ECOSM ; P0DM32, MSRB_ENTFA ; E6ESW1, MSRB_ENTFT ; DR B2VJ36, MSRB_ERWT9 ; B7LQ21, MSRB_ESCF3 ; Q2SJP9, MSRB_HAHCH ; DR Q9KCX2, MSRB_HALH5 ; Q9ZNJ9, MSRB_HATHI ; A4G5V5, MSRB_HERAR ; DR B5XS71, MSRB_KLEP3 ; A6T7R0, MSRB_KLEP7 ; Q9CJ17, MSRB_LACLA ; DR A2RHS0, MSRB_LACLM ; Q032Q9, MSRB_LACLS ; Q88W33, MSRB_LACPL ; DR Q6ADJ8, MSRB_LEIXX ; Q72NN2, MSRB_LEPIC ; Q8F7W8, MSRB_LEPIN ; DR Q1WVT3, MSRB_LIGS1 ; Q92AE9, MSRB_LISIN ; C1KWF8, MSRB_LISMC ; DR Q71YF7, MSRB_LISMF ; B8DDP3, MSRB_LISMH ; Q8Y641, MSRB_LISMO ; DR A0AJW4, MSRB_LISW6 ; B1HZH4, MSRB_LYSSC ; Q46EH1, MSRB_METBF ; DR Q8PWF5, MSRB_METMA ; A2SGN7, MSRB_METPP ; O26807, MSRB_METTH ; DR P47686, MSRB_MYCGE ; P75129, MSRB_MYCPN ; Q9CMB1, MSRB_PASMU ; DR Q6D4P7, MSRB_PECAS ; C6DGV8, MSRB_PECCP ; Q7N400, MSRB_PHOLL ; DR A1VNB7, MSRB_POLNA ; Q12AE4, MSRB_POLSJ ; Q48FR2, MSRB_PSE14 ; DR A6V3R3, MSRB_PSEA7 ; B7UUZ9, MSRB_PSEA8 ; Q02NZ0, MSRB_PSEAB ; DR Q9I016, MSRB_PSEAE ; Q1ID16, MSRB_PSEE4 ; Q4K8U5, MSRB_PSEF5 ; DR C3K735, MSRB_PSEFS ; A4XVB1, MSRB_PSEMY ; A5W756, MSRB_PSEP1 ; DR Q3K935, MSRB_PSEPF ; B0KUQ0, MSRB_PSEPG ; Q88LQ6, MSRB_PSEPK ; DR B1J4W5, MSRB_PSEPW ; Q885Q1, MSRB_PSESM ; Q4ZQC6, MSRB_PSEU2 ; DR Q8XYL1, MSRB_RALN1 ; Q21LK2, MSRB_SACD2 ; B5F860, MSRB_SALA4 ; DR A9MFH4, MSRB_SALAR ; B5FJF9, MSRB_SALDC ; B4TGC8, MSRB_SALHS ; DR B4T3Y1, MSRB_SALNS ; A9N292, MSRB_SALPB ; B4TUA8, MSRB_SALSV ; DR P65450, MSRB_SALTI ; P65449, MSRB_SALTY ; A8GFD8, MSRB_SERP5 ; DR Q321R4, MSRB_SHIBS ; Q32GC7, MSRB_SHIDS ; Q0T4Y5, MSRB_SHIF8 ; DR Q83L66, MSRB_SHIFL ; Q3Z2B6, MSRB_SHISS ; Q5WH73, MSRB_SHOC1 ; DR A7X2A9, MSRB_STAA1 ; A6U1P3, MSRB_STAA2 ; Q2FH15, MSRB_STAA3 ; DR P0A088, MSRB_STAA8 ; A5ISV4, MSRB_STAA9 ; Q2YY44, MSRB_STAAB ; DR A6QGX4, MSRB_STAAE ; P65451, MSRB_STAAM ; P99065, MSRB_STAAN ; DR Q6GGY4, MSRB_STAAR ; Q6G9D8, MSRB_STAAS ; A8Z402, MSRB_STAAT ; DR P0A087, MSRB_STAAW ; B9DNY9, MSRB_STACT ; Q5HPB4, MSRB_STAEQ ; DR Q8CSK6, MSRB_STAES ; Q4L6D3, MSRB_STAHJ ; Q49XN4, MSRB_STAS1 ; DR Q3K1F5, MSRB_STRA1 ; Q8E5Q9, MSRB_STRA3 ; Q8E026, MSRB_STRA5 ; DR C0M8H8, MSRB_STRE4 ; Q99ZV6, MSRB_STRP1 ; P0DC42, MSRB_STRP3 ; DR Q5XCD0, MSRB_STRP6 ; Q8P172, MSRB_STRP8 ; P0DC43, MSRB_STRPQ ; DR C0MDV8, MSRB_STRS7 ; A5GQT3, MSRB_SYNR3 ; C5BR54, MSRB_TERTT ; DR Q8DJK9, MSRB_THEVB ; Q3SJU1, MSRB_THIDA ; B8GMG5, MSRB_THISH ; DR C5CNS9, MSRB_VARPS ; A5F6R2, MSRB_VIBC3 ; Q9KQK0, MSRB_VIBCH ; DR C3LNU9, MSRB_VIBCM ; Q87MS5, MSRB_VIBPA ; Q8D849, MSRB_VIBVU ; DR Q7MMC4, MSRB_VIBVY ; B2I8Y4, MSRB_XYLF2 ; Q9PF29, MSRB_XYLFA ; DR Q87AJ9, MSRB_XYLFT ; A1JQG8, MSRB_YERE8 ; A7FI81, MSRB_YERP3 ; DR Q1C7U0, MSRB_YERPA ; B2K3R4, MSRB_YERPB ; Q8ZEK7, MSRB_YERPE ; DR A9R9C4, MSRB_YERPG ; Q1CJ76, MSRB_YERPN ; A4TJB4, MSRB_YERPP ; DR Q66AP6, MSRB_YERPS ; B1JLG2, MSRB_YERPY ; P25566, MXR2_YEAST ; //