ID   1.8.4.12
DE   Peptide-methionine (R)-S-oxide reductase.
AN   Methionine S-oxide reductase.
AN   Methionine S-oxide reductase (R-form oxidizing).
AN   Methionine sulfoxide reductase.
AN   Methionine sulfoxide reductase B.
AN   Selenoprotein R.
CA   Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-
CA   methionine (R)-S-oxide + thioredoxin.
CF   Selenium; Zinc.
CC   -!- The reaction occurs in the reverse direction to that shown above.
CC   -!- Exhibits high specificity for reduction of the R-form of methionine
CC       S-oxide, with higher activity being observed with L-methionine
CC       S-oxide than with D-methionine S-oxide.
CC   -!- While both free and protein-bound methionine (R)-S-oxide act as
CC       substrates, the activity with the peptide-bound form is far greater.
CC   -!- Plays a role in preventing oxidative-stress damage caused by reactive
CC       oxygen species by reducing the oxidized form of methionine back to
CC       methionine and thereby reactivating peptides that had been damaged.
CC   -!- The reaction proceeds via a sulfenic-acid intermediate.
CC   -!- For MsrB2 and MsrB3, thioredoxin is a poor reducing agent but
CC       thionein works well.
DR   P0A3Q9, MSAB1_STRPN;  P0A3R0, MSAB1_STRR6;  P65443, MSAB2_STRPN;
DR   P65444, MSAB2_STRR6;  Q9AL99, MSRAB_AGGAC;  Q93KF3, MSRAB_CAMFE;
DR   P86890, MSRAB_ENTFL;  P45213, MSRAB_HAEIN;  Q9ZMK8, MSRAB_HELPJ;
DR   O25011, MSRAB_HELPY;  P14930, MSRAB_NEIGO;  Q9JWM8, MSRAB_NEIMA;
DR   Q9K1N8, MSRAB_NEIMB;  Q9LAM9, MSRAB_STRGC;  Q99YT1, MSRAB_STRP1;
DR   P0DC40, MSRAB_STRP3;  Q5XAX5, MSRAB_STRP6;  Q8P046, MSRAB_STRP8;
DR   P0DC41, MSRAB_STRPQ;  O83641, MSRAB_TREPA;  Q9KLX6, MSRAB_VIBCH;
DR   Q9C8M2, MSRB1_ARATH;  Q0DC89, MSRB1_ORYSJ;  Q92RA4, MSRB1_RHIME;
DR   Q9C5C8, MSRB2_ARATH;  Q92Y46, MSRB2_RHIME;  Q9M0Z6, MSRB3_ARATH;
DR   Q6AUK5, MSRB3_ORYSJ;  Q9M0Z5, MSRB4_ARATH;  Q9ZS91, MSRB5_ARATH;
DR   Q10L32, MSRB5_ORYSJ;  Q8GWF4, MSRB6_ARATH;  Q8VY86, MSRB7_ARATH;
DR   O49707, MSRB8_ARATH;  Q84JT6, MSRB9_ARATH;  B0BYW4, MSRB_ACAM1 ;
DR   Q6FAL8, MSRB_ACIAD ;  B7H3X2, MSRB_ACIB3 ;  B7I415, MSRB_ACIB5 ;
DR   B2HYT2, MSRB_ACIBC ;  B0VR86, MSRB_ACIBS ;  A3M4Q3, MSRB_ACIBT ;
DR   B0VC45, MSRB_ACIBY ;  Q8UGX7, MSRB_AGRT5 ;  Q0A706, MSRB_ALHEH ;
DR   B4RUW0, MSRB_ALTMD ;  C1DRM1, MSRB_AZOVD ;  A7Z5S1, MSRB_BACA2 ;
DR   Q9KCX2, MSRB_BACHD ;  Q65ID2, MSRB_BACLD ;  A8FEA3, MSRB_BACP2 ;
DR   Q5WH73, MSRB_BACSK ;  P54155, MSRB_BACSU ;  Q89EM9, MSRB_BRAJA ;
DR   P65447, MSRB_BRUME ;  P65448, MSRB_BRUSU ;  B1YRN6, MSRB_BURA4 ;
DR   Q1BH71, MSRB_BURCA ;  B1JTT6, MSRB_BURCC ;  A0K833, MSRB_BURCH ;
DR   B4EBK9, MSRB_BURCJ ;  Q0BEH0, MSRB_BURCM ;  A9AJS6, MSRB_BURM1 ;
DR   A2SBI6, MSRB_BURM9 ;  Q62JM6, MSRB_BURMA ;  A1V4U8, MSRB_BURMS ;
DR   Q3JRF0, MSRB_BURP1 ;  Q63V23, MSRB_BURPS ;  Q39FG2, MSRB_BURS3 ;
DR   Q2SWN9, MSRB_BURTA ;  A4JEZ1, MSRB_BURVG ;  B8GY23, MSRB_CAUCN ;
DR   Q9A6B1, MSRB_CAUCR ;  B3PK10, MSRB_CELJU ;  Q1QXV3, MSRB_CHRSD ;
DR   Q97IU0, MSRB_CLOAB ;  Q9ZNJ9, MSRB_CLOHI ;  Q0TPZ6, MSRB_CLOP1 ;
DR   Q8XJZ6, MSRB_CLOPE ;  Q0SSL4, MSRB_CLOPS ;  Q47EU6, MSRB_DECAR ;
DR   Q9RUK6, MSRB_DEIRA ;  Q72EK2, MSRB_DESVH ;  A7ZMP8, MSRB_ECO24 ;
DR   B7USF8, MSRB_ECO27 ;  B7MAY9, MSRB_ECO45 ;  B7L6Q3, MSRB_ECO55 ;
DR   P0A748, MSRB_ECO57 ;  B5YQ71, MSRB_ECO5E ;  B7NSZ8, MSRB_ECO7I ;
DR   B7MVQ9, MSRB_ECO81 ;  B7M1J2, MSRB_ECO8A ;  C4ZZD4, MSRB_ECOBW ;
DR   B1XGN8, MSRB_ECODH ;  A8A0X0, MSRB_ECOHS ;  Q0TH50, MSRB_ECOL5 ;
DR   P0A747, MSRB_ECOL6 ;  B1IPF3, MSRB_ECOLC ;  P0A746, MSRB_ECOLI ;
DR   B7N5B4, MSRB_ECOLU ;  B6IBJ9, MSRB_ECOSE ;  B1LDV3, MSRB_ECOSM ;
DR   Q9XB39, MSRB_ENTFA ;  Q6D4P7, MSRB_ERWCT ;  B2VJ36, MSRB_ERWT9 ;
DR   B7LQ21, MSRB_ESCF3 ;  Q2SJP9, MSRB_HAHCH ;  A4G5V5, MSRB_HERAR ;
DR   B5XS71, MSRB_KLEP3 ;  A6T7R0, MSRB_KLEP7 ;  Q9CJ17, MSRB_LACLA ;
DR   A2RHS0, MSRB_LACLM ;  Q032Q9, MSRB_LACLS ;  Q88W33, MSRB_LACPL ;
DR   Q1WVT3, MSRB_LACS1 ;  Q6ADJ8, MSRB_LEIXX ;  Q72NN2, MSRB_LEPIC ;
DR   Q8F7W8, MSRB_LEPIN ;  Q92AE9, MSRB_LISIN ;  C1KWF8, MSRB_LISMC ;
DR   Q71YF7, MSRB_LISMF ;  B8DDP3, MSRB_LISMH ;  Q8Y641, MSRB_LISMO ;
DR   A0AJW4, MSRB_LISW6 ;  B1HZH4, MSRB_LYSSC ;  Q46EH1, MSRB_METBF ;
DR   Q8PWF5, MSRB_METMA ;  A2SGN7, MSRB_METPP ;  O26807, MSRB_METTH ;
DR   P47686, MSRB_MYCGE ;  P75129, MSRB_MYCPN ;  Q9CMB1, MSRB_PASMU ;
DR   C6DGV8, MSRB_PECCP ;  Q7N400, MSRB_PHOLL ;  A1VNB7, MSRB_POLNA ;
DR   Q12AE4, MSRB_POLSJ ;  Q48FR2, MSRB_PSE14 ;  A6V3R3, MSRB_PSEA7 ;
DR   B7UUZ9, MSRB_PSEA8 ;  Q02NZ0, MSRB_PSEAB ;  Q9I016, MSRB_PSEAE ;
DR   Q1ID16, MSRB_PSEE4 ;  Q4K8U5, MSRB_PSEF5 ;  C3K735, MSRB_PSEFS ;
DR   A4XVB1, MSRB_PSEMY ;  A5W756, MSRB_PSEP1 ;  Q3K935, MSRB_PSEPF ;
DR   B0KUQ0, MSRB_PSEPG ;  Q88LQ6, MSRB_PSEPK ;  B1J4W5, MSRB_PSEPW ;
DR   Q885Q1, MSRB_PSESM ;  Q4ZQC6, MSRB_PSEU2 ;  Q8XYL1, MSRB_RALSO ;
DR   Q21LK2, MSRB_SACD2 ;  B5F860, MSRB_SALA4 ;  A9MFH4, MSRB_SALAR ;
DR   B5FJF9, MSRB_SALDC ;  B4TGC8, MSRB_SALHS ;  B4T3Y1, MSRB_SALNS ;
DR   A9N292, MSRB_SALPB ;  B4TUA8, MSRB_SALSV ;  P65450, MSRB_SALTI ;
DR   P65449, MSRB_SALTY ;  A8GFD8, MSRB_SERP5 ;  Q321R4, MSRB_SHIBS ;
DR   Q32GC7, MSRB_SHIDS ;  Q0T4Y5, MSRB_SHIF8 ;  Q83L66, MSRB_SHIFL ;
DR   Q3Z2B6, MSRB_SHISS ;  A7X2A9, MSRB_STAA1 ;  A6U1P3, MSRB_STAA2 ;
DR   Q2FH15, MSRB_STAA3 ;  P0A088, MSRB_STAA8 ;  A5ISV4, MSRB_STAA9 ;
DR   Q2YY44, MSRB_STAAB ;  A6QGX4, MSRB_STAAE ;  P65451, MSRB_STAAM ;
DR   P99065, MSRB_STAAN ;  Q6GGY4, MSRB_STAAR ;  Q6G9D8, MSRB_STAAS ;
DR   A8Z402, MSRB_STAAT ;  P0A087, MSRB_STAAW ;  B9DNY9, MSRB_STACT ;
DR   Q5HPB4, MSRB_STAEQ ;  Q8CSK6, MSRB_STAES ;  Q4L6D3, MSRB_STAHJ ;
DR   Q49XN4, MSRB_STAS1 ;  Q3K1F5, MSRB_STRA1 ;  Q8E5Q9, MSRB_STRA3 ;
DR   Q8E026, MSRB_STRA5 ;  C0M8H8, MSRB_STRE4 ;  Q99ZV6, MSRB_STRP1 ;
DR   P0DC42, MSRB_STRP3 ;  Q5XCD0, MSRB_STRP6 ;  Q8P172, MSRB_STRP8 ;
DR   P0DC43, MSRB_STRPQ ;  C0MDV8, MSRB_STRS7 ;  A5GQT3, MSRB_SYNR3 ;
DR   C5BR54, MSRB_TERTT ;  Q8DJK9, MSRB_THEEB ;  Q3SJU1, MSRB_THIDA ;
DR   B8GMG5, MSRB_THISH ;  C5CNS9, MSRB_VARPS ;  A5F6R2, MSRB_VIBC3 ;
DR   Q9KQK0, MSRB_VIBCH ;  C3LNU9, MSRB_VIBCM ;  Q87MS5, MSRB_VIBPA ;
DR   Q8D849, MSRB_VIBVU ;  Q7MMC4, MSRB_VIBVY ;  B2I8Y4, MSRB_XYLF2 ;
DR   Q9PF29, MSRB_XYLFA ;  Q87AJ9, MSRB_XYLFT ;  A1JQG8, MSRB_YERE8 ;
DR   A7FI81, MSRB_YERP3 ;  Q1C7U0, MSRB_YERPA ;  B2K3R4, MSRB_YERPB ;
DR   Q8ZEK7, MSRB_YERPE ;  A9R9C4, MSRB_YERPG ;  Q1CJ76, MSRB_YERPN ;
DR   A4TJB4, MSRB_YERPP ;  Q66AP6, MSRB_YERPS ;  B1JLG2, MSRB_YERPY ;
DR   P25566, MXR2_YEAST ;
//