ID   1.8.98.4
DE   coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
CA   coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-
CA   Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B
CA   heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme
CA   F420-(gamma-L-Glu)(n).
CC   -!- The enzyme, characterized from the archaeon Methanosarcina
CC       acetivorans, catalyzes the reduction of CoB-CoM heterodisulfide back
CC       to CoB and CoM.
CC   -!- The enzyme consists of three components, HdrA, HdrB and HdrC, all of
CC       which contain [4Fe-4S] clusters.
CC   -!- Electrons enter at HdrA, which also contains FAD, and are transferred
CC       via HdrC to the catalytic component, HdrB.
CC   -!- During methanogenesis from acetate the enzyme catalyzes the activity
CC       of EC 1.8.7.3.
CC   -!- However, it can also use electron bifurcation to direct electron
CC       pairs from reduced coenzyme F420 toward the reduction of both
CC       ferredoxin and CoB-CoM heterodisulfide.
CC   -!- This activity is proposed to take place during Fe(III)-dependent
CC       anaerobic methane oxidation. cf. EC 1.8.98.5, EC 1.8.98.6,
CC       and EC 1.8.98.1.
DR   Q8TM02, HDRA2_METAC;  Q8TIB8, HDRB2_METAC;  Q8TIB9, HDRC2_METAC;
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