ID   1.9.3.1
DE   Cytochrome-c oxidase.
AN   Complex IV (mitochondrial electron transport).
AN   Cytochrome a3.
AN   Cytochrome aa3.
AN   Cytochrome oxidase.
AN   Warburg's respiratory enzyme.
CA   4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
CF   Copper.
CC   -!- The reduction of O(2) to water is accompanied by the extrusion of
CC       four protons from the intramitochondrial compartment.
CC   -!- Several bacteria appear to contain analogous oxidases.
PR   PROSITE; PDOC00074;
PR   PROSITE; PDOC00075;
PR   PROSITE; PDOC00663;
DR   P98005, COX13_THET8;  P98057, COX14_BRAJA;  Q5YRP8, COX1A_NOCFA;
DR   P08305, COX1A_PARDE;  Q82AK9, COX1A_STRAW;  Q9X813, COX1A_STRCO;
DR   Q5Z0K2, COX1B_NOCFA;  P98002, COX1B_PARDE;  Q828X4, COX1B_STRAW;
DR   Q9K451, COX1B_STRCO;  Q37370, COX1_ACACA ;  B0FWC7, COX1_AEDAE ;
DR   P68540, COX1_AEGCO ;  P48887, COX1_ALBCO ;  Q09333, COX1_ALBTU ;
DR   P80440, COX1_ALLMA ;  P29643, COX1_AMICA ;  P50656, COX1_ANAPL ;
DR   P34838, COX1_ANOGA ;  P33504, COX1_ANOQU ;  P20374, COX1_APILI ;
DR   O03515, COX1_APTAU ;  P60620, COX1_ARATH ;  Q37705, COX1_ARTSF ;
DR   P24881, COX1_ASCSU ;  P62514, COX1_ASHGO ;  Q33820, COX1_ASTPE ;
DR   P29644, COX1_ATRSP ;  P16262, COX1_BACP3 ;  Q04440, COX1_BACPE ;
DR   P24010, COX1_BACSU ;  Q599A1, COX1_BALBO ;  P41293, COX1_BALMU ;
DR   P24983, COX1_BALPH ;  P24794, COX1_BETVU ;  Q36724, COX1_BLAGE ;
DR   Q6EMS9, COX1_BOSIN ;  Q5Y4Q8, COX1_BOSMU ;  P00396, COX1_BOVIN ;
DR   P31833, COX1_BRAJA ;  Q94WR7, COX1_BUTBU ;  P24893, COX1_CAEEL ;
DR   P0C8K9, COX1_CANAL ;  Q9ZZ64, COX1_CANFA ;  Q85QA3, COX1_CANGA ;
DR   Q1HKA1, COX1_CANLU ;  Q33375, COX1_CANSI ;  Q36347, COX1_CAPHI ;
DR   O78681, COX1_CARAU ;  O03521, COX1_CASBE ;  O03198, COX1_CERSI ;
DR   P18943, COX1_CHICK ;  P08681, COX1_CHLRE ;  P50668, COX1_CHOBI ;
DR   P48866, COX1_CHOCR ;  P50669, COX1_CHOFU ;  P67793, COX1_CHOOC ;
DR   P67794, COX1_CHOPI ;  P50671, COX1_CHORO ;  Q9B229, COX1_CHRKN ;
DR   O99041, COX1_COLPO ;  Q6NFM3, COX1_CORDI ;  Q8FMT1, COX1_COREF ;
DR   Q79VD7, COX1_CORGL ;  P24984, COX1_COTJA ;  Q6EGJ1, COX1_CRANE ;
DR   Q6EGJ0, COX1_CRAZI ;  P98003, COX1_CRION ;  P48867, COX1_CYACA ;
DR   P24985, COX1_CYPCA ;  Q9MIY8, COX1_DANRE ;  O21327, COX1_DASNO ;
DR   A9RAH5, COX1_DEBHA ;  Q2LCQ6, COX1_DICCI ;  O21042, COX1_DICDI ;
DR   P41310, COX1_DIDMA ;  O79548, COX1_DINSE ;  Q34345, COX1_DROMA ;
DR   P00399, COX1_DROME ;  O03524, COX1_DRONO ;  Q34391, COX1_DROSE ;
DR   Q34388, COX1_DROSI ;  P00400, COX1_DROYA ;  Q8W9N4, COX1_DUGDU ;
DR   Q2I3H2, COX1_ELEMA ;  P00402, COX1_EMEND ;  Q33439, COX1_EPHEQ ;
DR   P92477, COX1_EQUAS ;  P48888, COX1_FELCA ;  P34188, COX1_FORLA ;
DR   Q36775, COX1_GADMO ;  Q6EGH9, COX1_GEOBE ;  P29645, COX1_GEOSD ;
DR   Q6EGH8, COX1_GEOTE ;  P29646, COX1_GOMVA ;  P38595, COX1_HALGR ;
DR   P33518, COX1_HALSA ;  Q9ZZ08, COX1_HAPMA ;  Q9ZZY9, COX1_HIPAM ;
DR   P48659, COX1_HORSE ;  P00395, COX1_HUMAN ;  Q7GEN7, COX1_HYLLA ;
DR   Q34800, COX1_HYLSY ;  P20386, COX1_KLULA ;  O03167, COX1_LATCH ;
DR   P14544, COX1_LEITA ;  Q8LX30, COX1_LEMCA ;  P29647, COX1_LEPOC ;
DR   Q36421, COX1_LOCMI ;  Q9TGE6, COX1_LOLFO ;  Q8WEW4, COX1_LOLPE ;
DR   Q9TA27, COX1_LOXAF ;  Q34941, COX1_LUMTE ;  P92661, COX1_MACRO ;
DR   P08742, COX1_MAIZE ;  Q38PS0, COX1_MAMPR ;  P26856, COX1_MARPO ;
DR   P29648, COX1_MEGAT ;  Q35101, COX1_METSE ;  P00397, COX1_MOUSE ;
DR   P63853, COX1_MYCBO ;  Q9CBQ5, COX1_MYCLE ;  Q73VC3, COX1_MYCPA ;
DR   P63852, COX1_MYCTU ;  P41774, COX1_MYTED ;  O21079, COX1_MYXGL ;
DR   P03945, COX1_NEUCR ;  O03539, COX1_NOTPE ;  Q9G6J1, COX1_OCTVU ;
DR   P08743, COX1_OENBE ;  P48170, COX1_ONCMY ;  Q36452, COX1_ORNAN ;
DR   Q6EGI5, COX1_ORTCH ;  Q6EGI2, COX1_ORTGR ;  Q6EGI3, COX1_ORTHI ;
DR   Q6EGI4, COX1_ORTUN ;  P14578, COX1_ORYSJ ;  Q9B840, COX1_OSTNU ;
DR   P29649, COX1_PANBU ;  Q9T9X0, COX1_PANPA ;  Q9T9W1, COX1_PANTR ;
DR   Q6EGI0, COX1_PAPBU ;  Q9ZXY2, COX1_PAPHA ;  P12700, COX1_PARLI ;
DR   P05489, COX1_PARTE ;  Q00502, COX1_PARVE ;  P12786, COX1_PEA   ;
DR   Q96000, COX1_PECMA ;  O79672, COX1_PELSU ;  Q35536, COX1_PETMA ;
DR   Q00527, COX1_PHOVI ;  Q02211, COX1_PHYME ;  Q07434, COX1_PHYPO ;
DR   P48868, COX1_PICCA ;  O79876, COX1_PIG   ;  P25001, COX1_PISOC ;
DR   O99252, COX1_PLABE ;  O99255, COX1_PLACH ;  Q9TGD8, COX1_PLADA ;
DR   Q02766, COX1_PLAFA ;  P20681, COX1_PODAN ;  Q95911, COX1_POLOR ;
DR   P29650, COX1_POLSP ;  P29651, COX1_POLSX ;  P29652, COX1_POMNI ;
DR   P92692, COX1_PONAB ;  Q05143, COX1_PROWI ;  O79429, COX1_RABIT ;
DR   P60621, COX1_RAPSA ;  P05503, COX1_RAT   ;  O03546, COX1_RHEAM ;
DR   Q08855, COX1_RHILE ;  O99818, COX1_RHISA ;  Q96062, COX1_RHIUN ;
DR   P98059, COX1_RHOCA ;  P33517, COX1_RHOSH ;  Q1RI42, COX1_RICBR ;
DR   Q92I67, COX1_RICCN ;  Q4ULU5, COX1_RICFE ;  O54069, COX1_RICPR ;
DR   P98001, COX1_SACDO ;  Q9ZZM6, COX1_SALSA ;  P29653, COX1_SALTR ;
DR   P29654, COX1_SCAPL ;  P07657, COX1_SCHPO ;  O79403, COX1_SCYCA ;
DR   Q8WEW3, COX1_SEPOF ;  Q957T2, COX1_SEPPH ;  O78749, COX1_SHEEP ;
DR   P05502, COX1_SORBI ;  P07506, COX1_SOYBN ;  Q9ZZ52, COX1_SQUAC ;
DR   O21399, COX1_STRCA ;  P15544, COX1_STRPU ;  Q06473, COX1_SYNY3 ;
DR   Q4JQI5, COX1_TETNG ;  P11947, COX1_TETPY ;  Q4UJ69, COX1_THEAN ;
DR   Q36097, COX1_THEPA ;  Q5SJ79, COX1_THET8 ;  Q56408, COX1_THETH ;
DR   P50676, COX1_THEVL ;  O03554, COX1_TINMA ;  Q01555, COX1_TRIRU ;
DR   P04371, COX1_TRYBB ;  Q0H8Y4, COX1_USTMA ;  A6H4Q6, COX1_VANPO ;
DR   P68539, COX1_WHEAT ;  P00398, COX1_XENLA ;  Q9B6E7, COX1_YARLI ;
DR   P00401, COX1_YEAST ;  Q6EGH7, COX1_ZYGTR ;  P29870, COX2_ACHDO ;
DR   P29871, COX2_ADABI ;  P50692, COX2_AEDAE ;  P48889, COX2_ALBCO ;
DR   Q09334, COX2_ALBTU ;  O47870, COX2_ALLMI ;  P29655, COX2_AMICA ;
DR   P98019, COX2_ANAPL ;  P34840, COX2_ANOGA ;  P33505, COX2_ANOQU ;
DR   P50267, COX2_APIFL ;  P50268, COX2_APIKO ;  P20375, COX2_APILI ;
DR   O03889, COX2_APTAU ;  P93285, COX2_ARATH ;  Q37706, COX2_ARTSF ;
DR   P24882, COX2_ASCSU ;  Q7YFV7, COX2_ASHGO ;  Q37411, COX2_ASTPE ;
DR   P29656, COX2_ATRSP ;  Q03438, COX2_BACP3 ;  Q04441, COX2_BACPE ;
DR   P24011, COX2_BACSU ;  P98012, COX2_BETVU ;  O47428, COX2_BRAFL ;
DR   O79417, COX2_BRALA ;  P43369, COX2_BREAN ;  P43370, COX2_BRECS ;
DR   P43372, COX2_BRENA ;  Q8HEC3, COX2_CAEBR ;  P24894, COX2_CAEEL ;
DR   Q8SEM9, COX2_CAERE ;  P50666, COX2_CAIMO ;  Q9B8D8, COX2_CANAL ;
DR   P43373, COX2_CANGA ;  O78682, COX2_CARAU ;  O03890, COX2_CASBE ;
DR   P18944, COX2_CHICK ;  P98025, COX2_CHOBI ;  P48869, COX2_CHOCR ;
DR   P84288, COX2_CHOFU ;  P84289, COX2_CHOOC ;  P84290, COX2_CHOPI ;
DR   P98030, COX2_CHORO ;  Q6NG98, COX2_CORDI ;  Q8FNQ7, COX2_COREF ;
DR   Q8NNK2, COX2_CORGL ;  P50684, COX2_COTJA ;  P29872, COX2_CTEFE ;
DR   P50693, COX2_CULQU ;  P48870, COX2_CYACA ;  P47918, COX2_CYBMR ;
DR   P06029, COX2_CYBSA ;  P24987, COX2_CYPCA ;  Q9MIY7, COX2_DANRE ;
DR   P27168, COX2_DAUCA ;  A9RAG1, COX2_DEBHA ;  P43374, COX2_DEKBR ;
DR   O79549, COX2_DINSE ;  Q85TA0, COX2_DROAI ;  P84201, COX2_DROAL ;
DR   P29856, COX2_DROAM ;  P84202, COX2_DROAT ;  P84287, COX2_DROAZ ;
DR   P29859, COX2_DROBF ;  P29860, COX2_DROLO ;  P00408, COX2_DROME ;
DR   P67797, COX2_DROMI ;  O03891, COX2_DRONO ;  P67795, COX2_DRONR ;
DR   P67798, COX2_DROPE ;  P67799, COX2_DROPS ;  P50253, COX2_DROSI ;
DR   P29865, COX2_DROSU ;  P67796, COX2_DROTO ;  P00409, COX2_DROYA ;
DR   P43375, COX2_EENNA ;  P13588, COX2_EMEND ;  P29873, COX2_EXERO ;
DR   P34189, COX2_FORLA ;  Q37741, COX2_GADMO ;  P29874, COX2_GALME ;
DR   P29657, COX2_GEOSD ;  P29658, COX2_GOMVA ;  P20387, COX2_KLULA ;
DR   Q9XLW8, COX2_LACKL ;  P43376, COX2_LACTC ;  P29875, COX2_LASSP ;
DR   O03848, COX2_LATCH ;  P14545, COX2_LEITA ;  P29659, COX2_LEPOC ;
DR   P14573, COX2_LOCMI ;  Q37545, COX2_LUMTE ;  P00412, COX2_MAIZE ;
DR   P26857, COX2_MARPO ;  P29660, COX2_MEGAT ;  O47496, COX2_METSE ;
DR   P63855, COX2_MYCBO ;  Q9CCF1, COX2_MYCLE ;  Q73YL5, COX2_MYCPA ;
DR   P63854, COX2_MYCTU ;  Q00227, COX2_MYTED ;  Q9G2X2, COX2_MYXGL ;
DR   P00411, COX2_NEUCR ;  Q5YZ37, COX2_NOCFA ;  O03892, COX2_NOTPE ;
DR   P05490, COX2_OENBE ;  P29876, COX2_ONCFA ;  P48171, COX2_ONCMY ;
DR   P04373, COX2_ORYSJ ;  P08306, COX2_PARDE ;  P12701, COX2_PARLI ;
DR   P08748, COX2_PARPR ;  P08749, COX2_PARTE ;  P08744, COX2_PEA   ;
DR   O79673, COX2_PELSU ;  P29877, COX2_PERAM ;  Q37604, COX2_PETMA ;
DR   Q02212, COX2_PHYME ;  P48871, COX2_PICCA ;  P25002, COX2_PISOC ;
DR   P29163, COX2_PNECA ;  P20682, COX2_PODAN ;  Q96183, COX2_POLOR ;
DR   P29661, COX2_POLSX ;  O03893, COX2_RHEAM ;  O99819, COX2_RHISA ;
DR   Q03736, COX2_RHOSH ;  Q1RI44, COX2_RICBR ;  Q92I65, COX2_RICCN ;
DR   Q4ULU3, COX2_RICFE ;  Q9ZDC6, COX2_RICPR ;  P43377, COX2_SACEX ;
DR   Q37677, COX2_SALSA ;  P29662, COX2_SCAPL ;  P29878, COX2_SCHGR ;
DR   P21534, COX2_SCHPO ;  O79404, COX2_SCYCA ;  P98021, COX2_SIMVI ;
DR   P29879, COX2_SITGR ;  Q3T4C0, COX2_SMICU ;  P80498, COX2_SOLTU ;
DR   P05491, COX2_SOYBN ;  Q9ZZ51, COX2_SQUAC ;  Q82AL0, COX2_STRAW ;
DR   O21400, COX2_STRCA ;  Q9X814, COX2_STRCO ;  P15545, COX2_STRPU ;
DR   P29880, COX2_SYMST ;  Q06474, COX2_SYNY3 ;  Q4JQI4, COX2_TETNG ;
DR   Q5SJ80, COX2_THET8 ;  P98052, COX2_THETH ;  P98054, COX2_THEVL ;
DR   O03895, COX2_TINMA ;  Q01556, COX2_TRIRU ;  P04372, COX2_TRYBB ;
DR   P98023, COX2_TRYCR ;  Q0H8Y7, COX2_USTMA ;  A6H4Q5, COX2_VANPO ;
DR   P32646, COX2_VIGUN ;  P00413, COX2_WHEAT ;  P00407, COX2_XENLA ;
DR   Q9B6D5, COX2_YARLI ;  P00410, COX2_YEAST ;  P98048, COX2_YPOMA ;
DR   P29881, COX2_ZOOAN ;  Q37374, COX3_ACACA ;  B0FWD1, COX3_AEDAE ;
DR   Q36952, COX3_AEGCO ;  P48891, COX3_ALBCO ;  P80439, COX3_ALLMA ;
DR   P50657, COX3_ANAPL ;  P34842, COX3_ANOGA ;  P33508, COX3_ANOQU ;
DR   P34843, COX3_APILI ;  P92514, COX3_ARATH ;  Q33752, COX3_ARBLI ;
DR   Q33845, COX3_ARTSA ;  Q36309, COX3_ARTSF ;  P24879, COX3_ASCSU ;
DR   Q75G34, COX3_ASHGO ;  Q33824, COX3_ASTPE ;  Q03439, COX3_BACP3 ;
DR   Q04442, COX3_BACPE ;  P24012, COX3_BACSU ;  P69216, COX3_BRAFL ;
DR   P69215, COX3_BRALA ;  P24891, COX3_CAEEL ;  Q9B1P9, COX3_CANAL ;
DR   Q85Q96, COX3_CANGA ;  Q34214, COX3_CANPA ;  Q96133, COX3_CARAU ;
DR   P18945, COX3_CHICK ;  P48872, COX3_CHOCR ;  Q6NGA0, COX3_CORDI ;
DR   Q8FNQ9, COX3_COREF ;  Q9AEL8, COX3_CORGL ;  Q8SEW8, COX3_COTJA ;
DR   P48873, COX3_CYACA ;  P15952, COX3_CYPCA ;  Q9MIY4, COX3_DANRE ;
DR   A9RAG9, COX3_DEBHA ;  Q2LCP9, COX3_DICCI ;  O21049, COX3_DICDI ;
DR   O79552, COX3_DINSE ;  P00417, COX3_DROME ;  P50271, COX3_DROSI ;
DR   P00418, COX3_DROYA ;  P00421, COX3_EMEND ;  Q35242, COX3_ENTDO ;
DR   P34198, COX3_FORLA ;  P55777, COX3_GADMO ;  P32808, COX3_HELAN ;
DR   Q9XLW9, COX3_KLULA ;  Q9XLX0, COX3_LACKL ;  O03170, COX3_LATCH ;
DR   P14546, COX3_LEITA ;  P14574, COX3_LOCMI ;  O47475, COX3_LOLBL ;
DR   Q34943, COX3_LUMTE ;  Q95840, COX3_MAGGR ;  P09138, COX3_MAIZE ;
DR   P26858, COX3_MARPO ;  O47491, COX3_METSE ;  P63857, COX3_MYCBO ;
DR   O69582, COX3_MYCLE ;  Q73YM3, COX3_MYCPA ;  P63856, COX3_MYCTU ;
DR   P41775, COX3_MYTED ;  O63915, COX3_MYXGL ;  P00422, COX3_NEUCR ;
DR   Q5YZ19, COX3_NOCFA ;  P08745, COX3_OENBE ;  P20684, COX3_ONCCL ;
DR   P69217, COX3_ONCMA ;  P48172, COX3_ONCMY ;  P69218, COX3_ONCNE ;
DR   P14852, COX3_ORYSI ;  P06030, COX3_PARDE ;  P12702, COX3_PARLI ;
DR   O79676, COX3_PELSU ;  Q35539, COX3_PETMA ;  P48874, COX3_PICCA ;
DR   P25003, COX3_PISOC ;  Q36675, COX3_PLAVI ;  Q02654, COX3_PODAN ;
DR   Q95914, COX3_POLOR ;  Q37620, COX3_PROWI ;  Q37600, COX3_PYLLI ;
DR   O99822, COX3_RHISA ;  P80441, COX3_RHIST ;  Q1RHH9, COX3_RICBR ;
DR   Q92J29, COX3_RICCN ;  Q4UKK0, COX3_RICFE ;  Q9ZDX3, COX3_RICPR ;
DR   Q36860, COX3_SALSA ;  P14058, COX3_SCHCO ;  P14575, COX3_SCHPO ;
DR   O79407, COX3_SCYCA ;  P14853, COX3_SOYBN ;  Q35826, COX3_SPOFR ;
DR   Q9ZZ48, COX3_SQUAC ;  Q82AK5, COX3_STRAW ;  O21403, COX3_STRCA ;
DR   Q9X809, COX3_STRCO ;  P15546, COX3_STRPU ;  Q06475, COX3_SYNY3 ;
DR   Q4JQI1, COX3_TETNG ;  Q37679, COX3_THEAN ;  Q36098, COX3_THEPA ;
DR   P50677, COX3_THEVL ;  Q36837, COX3_TRIRU ;  Q37355, COX3_TRYBO ;
DR   Q0H8X4, COX3_USTMA ;  A6H4Q3, COX3_VANPO ;  Q03227, COX3_VICFA ;
DR   P15953, COX3_WHEAT ;  P00419, COX3_XENLA ;  Q9B6D8, COX3_YARLI ;
DR   P00420, COX3_YEAST ;  Q9I8U0, COX41_THUOB;  P80971, COX42_THUOB;
DR   Q03440, COX4_BACP3 ;  Q04452, COX4_BACPE ;  P24013, COX4_BACSU ;
DR   Q6NG99, COX4_CORDI ;  Q8FNQ8, COX4_COREF ;  Q8NNK3, COX4_CORGL ;
DR   P30815, COX4_DICDI ;  P64948, COX4_MYCBO ;  Q9CCF0, COX4_MYCLE ;
DR   Q73YL6, COX4_MYCPA ;  P64947, COX4_MYCTU ;  Q5YZ36, COX4_NOCFA ;
DR   P80327, COX4_ONCMY ;  P77921, COX4_PARDE ;  Q82AK8, COX4_STRAW ;
DR   Q9X812, COX4_STRCO ;  P00424, COX5A_YEAST;  P00425, COX5B_YEAST;
DR   O93980, COX5_ASPNG ;  P06810, COX5_NEUCR ;  O74988, COX5_SCHPO ;
DR   P26310, COX6_DICDI ;  Q9VHS2, COX7A_DROME;  P80979, COX7A_THUOB;
DR   P80334, COX7C_ONCMY;  P80982, COX7C_THUOB;  G2TRP5, COX7_SCHPO ;
DR   P10174, COX7_YEAST ;  Q9P4W1, COX8_SCHPO ;  P04039, COX8_YEAST ;
DR   Q757F0, COX9_ASHGO ;  Q6FWE8, COX9_CANGA ;  Q6BPV1, COX9_DEBHA ;
DR   Q6CWK9, COX9_KLULA ;  O94705, COX9_SCHPO ;  P07255, COX9_YEAST ;
DR   P82543, COXA_THET8 ;  P20609, COXE_DICDI ;  P98053, COXM_BRAJA ;
DR   P80981, COXM_THUOB ;  P98000, COXN_BRAJA ;  P80980, COXN_THUOB ;
DR   P20610, COXS_DICDI ;  Q02226, COXT_SOYBN ;  P80333, CX7A1_ONCMY;
DR   P80332, CX7A2_ONCMY;  P98055, FIXN_AGRT7 ;  P98056, FIXN_AZOC5 ;
DR   Q03073, FIXN_BRAJA ;  Q05572, FIXN_RHIME ;
//