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ENZYME entry: EC 1.97.1.4

Accepted Name
[Formate-C-acetyltransferase]-activating enzyme.
Alternative Name(s)
[Pyruvate formate-lyase]-activating enzyme.
Formate acetyltransferase activating enzyme.
Formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L- methionine oxidoreductase (S-adenosyl-L-methionine cleaving).
PFL activase.
PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving).
Reaction catalysed
S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine <=> 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical
Cofactor(s)
Iron-sulfur.
Comment(s)
  • A single glycine residue in EC 2.3.1.54 is oxidized to the corresponding radical by transfer of H from its CH(2) to AdoMet with concomitant cleavage of the latter.
  • The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen radical from the glycine residue.
Cross-references
PROSITEPDOC00834
BRENDA1.97.1.4
EC2PDB1.97.1.4
ExplorEnz1.97.1.4
PRIAM enzyme-specific profiles1.97.1.4
KEGG Ligand Database for Enzyme Nomenclature1.97.1.4
IUBMB Enzyme Nomenclature1.97.1.4
IntEnz1.97.1.4
MEDLINEFind literature relating to 1.97.1.4
MetaCyc1.97.1.4
UniProtKB/Swiss-Prot
Q46267, PFLA_CLOPA;  P0A9N6, PFLA_ECO57;  P0A9N5, PFLA_ECOL6;  
P0A9N4, PFLA_ECOLI;  P43751, PFLA_HAEIN;  P0A443, PFLA_LISIN;  
Q71ZR3, PFLA_LISMF;  P0A442, PFLA_LISMO;  P0A9N7, PFLA_SHIFL;  
Q2FK43, PFLA_STAA3;  Q2G1D7, PFLA_STAA8;  Q2YV52, PFLA_STAAB;  
Q5HJF3, PFLA_STAAC;  Q99WZ6, PFLA_STAAM;  Q7A7X5, PFLA_STAAN;  
Q6GK89, PFLA_STAAR;  Q6GCP9, PFLA_STAAS;  Q7A1W8, PFLA_STAAW;  
Q5HKI0, PFLA_STAEQ;  Q8CTX5, PFLA_STAES;  O68575, PFLA_STRMU;  
P32675, PFLC_ECOLI;  P75794, PFLE_ECOLI;  

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