ENZYME entry: EC 1.97.1.4
| Accepted Name |
|---|
| [Formate-C-acetyltransferase]-activating enzyme.
|
| Alternative Name(s) |
|---|
| [Pyruvate formate-lyase]-activating enzyme. |
| Formate acetyltransferase activating enzyme. |
| Formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-
methionine oxidoreductase (S-adenosyl-L-methionine cleaving). |
| PFL activase. |
| PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing,
S-adenosyl-L-methionine-cleaving). |
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine <=> 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical |
| Cofactor(s) |
|---|
| Iron-sulfur.
|
| Comment(s) |
|---|
- A single glycine residue in EC 2.3.1.54 is oxidized to the
corresponding radical by transfer of H from its CH(2) to AdoMet with
concomitant cleavage of the latter.
- The first stage is reduction of the AdoMet to give methionine and the
5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen
radical from the glycine residue.
|
| Cross-references |
|---|
| PROSITE | PDOC00834 |
| BRENDA | 1.97.1.4 |
| EC2PDB | 1.97.1.4 |
| ExplorEnz | 1.97.1.4 |
| PRIAM enzyme-specific profiles | 1.97.1.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.97.1.4 |
| IUBMB Enzyme Nomenclature | 1.97.1.4 |
| IntEnz | 1.97.1.4 |
| MEDLINE | Find literature relating to 1.97.1.4 |
| MetaCyc | 1.97.1.4 |
| UniProtKB/Swiss-Prot |
| Q46267, PFLA_CLOPA; | P0A9N6, PFLA_ECO57; | P0A9N5, PFLA_ECOL6; |
| P0A9N4, PFLA_ECOLI; | P43751, PFLA_HAEIN; | P0A443, PFLA_LISIN; |
| Q71ZR3, PFLA_LISMF; | P0A442, PFLA_LISMO; | P0A9N7, PFLA_SHIFL; |
| Q2FK43, PFLA_STAA3; | Q2G1D7, PFLA_STAA8; | Q2YV52, PFLA_STAAB; |
| Q5HJF3, PFLA_STAAC; | Q99WZ6, PFLA_STAAM; | Q7A7X5, PFLA_STAAN; |
| Q6GK89, PFLA_STAAR; | Q6GCP9, PFLA_STAAS; | Q7A1W8, PFLA_STAAW; |
| Q5HKI0, PFLA_STAEQ; | Q8CTX5, PFLA_STAES; | O68575, PFLA_STRMU; |
| P32675, PFLC_ECOLI; | P75794, PFLE_ECOLI; |
|
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