ENZYME entry: EC 2.1.1.100

Accepted Name
Protein-S-isoprenylcysteine O-methyltransferase.
Alternative Name(s)
Isoprenylcysteine carboxylmethyltransferase.
Prenylated protein carboxyl methyltransferase.
Prenylcysteine carboxyl methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine <=> S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
Comment(s)
  • C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, more slowly.
  • Formerly EC 2.1.1.24.
Cross-references
BRENDA2.1.1.100
EC2PDB2.1.1.100
ExplorEnz2.1.1.100
PRIAM enzyme-specific profiles2.1.1.100
KEGG Ligand Database for Enzyme Nomenclature2.1.1.100
IUBMB Enzyme Nomenclature2.1.1.100
IntEnz2.1.1.100
MEDLINEFind literature relating to 2.1.1.100
MetaCyc2.1.1.100
UniProtKB/Swiss-Prot
Q9FMW9, ICMTA_ARATH;  Q93W54, ICMTB_ARATH;  Q558K8, ICMT_DICDI;  
O60725, ICMT_HUMAN;  Q9EQK7, ICMT_MOUSE;  A2XX73, ICMT_ORYSI;  
Q7XSR9, ICMT_ORYSJ;  Q9WVM4, ICMT_RAT;  O12947, ICMT_XENLA;  
P87014, MAM4_SCHPO;  P32584, STE14_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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