ENZYME entry: EC 2.1.1.102

Accepted Name
Demethylmacrocin O-methyltransferase.
Alternative Name(s)
DMOMT.
Reaction catalysed
S-adenosyl-L-methionine + demethylmacrocin <=> S-adenosyl-L-homocysteine + macrocin
Cofactor(s)
Mg(2+).
Comment(s)
  • The 2-hydroxyl group of a 6-deoxy-D-allose residue in demethylmacrocin acts as methyl acceptor.
  • Isolated from Streptomyces fradiae.
  • Also acts on demethyllactenocin giving lactenocin.
  • Involved in the biosynthesis of the macrolide antibiotic tylosin.
  • Not identical with EC 2.1.1.101.
Cross-references
BRENDA2.1.1.102
EC2PDB2.1.1.102
ExplorEnz2.1.1.102
PRIAM enzyme-specific profiles2.1.1.102
KEGG Ligand Database for Enzyme Nomenclature2.1.1.102
IUBMB Enzyme Nomenclature2.1.1.102
IntEnz2.1.1.102
MEDLINEFind literature relating to 2.1.1.102
MetaCyc2.1.1.102
UniProtKB/Swiss-Prot
Q9ZHQ4, TYLE_STRFR

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