ID   2.1.1.107
DE   uroporphyrinogen-III C-methyltransferase.
AN   adenosylmethionine-uroporphyrinogen III methyltransferase.
AN   S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase.
AN   SUMT.
AN   urogen III methylase.
AN   uroporphyrin-III C-methyltransferase.
AN   uroporphyrinogen III methylase.
AN   uroporphyrinogen-III methylase.
AN   uroporphyrinogen-III methyltransferase.
AN   uroporphyrinogen methyltransferase.
CA   2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 +
CA   2 S-adenosyl-L-homocysteine.
CC   -!- This enzyme catalyzes two sequential methylation reactions, the first
CC       forming precorrin-1 and the second leading to the formation of
CC       precorrin-2.
CC   -!- It is the first of three steps leading to the formation of siroheme
CC       from uroporphyrinogen III.
CC   -!- The second step involves an NAD(+)-dependent dehydrogenation to form
CC       sirohydrochlorin from precorrin-2 (EC 1.3.1.76) and the third step
CC       involves the chelation of Fe(2+) to sirohydrochlorin to form siroheme
CC       (EC 4.99.1.4).
CC   -!- In Saccharomyces cerevisiae, the last two steps are carried out by a
CC       single bifunctional enzyme, Met8p.
CC   -!- In some bacteria, steps 1-3 are catalyzed by a single multifunctional
CC       protein called CysG, whereas in Bacillus megaterium, three separate
CC       enzymes carry out each of the steps, with SirA being responsible for
CC       the above reaction.
CC   -!- Also involved in the biosynthesis of cobalamin.
DR   A0KLD7, CYSG1_AERHH;  A4SHL4, CYSG1_AERS4;  A7MJ67, CYSG1_CROS8;
DR   A1WWP8, CYSG1_HALHL;  A6TD45, CYSG1_KLEP7;  Q6D1A4, CYSG1_PECAS;
DR   A8G9Y3, CYSG1_SERP5;  A1JJS8, CYSG1_YERE8;  A7FLY4, CYSG1_YERP3;
DR   Q1CLS2, CYSG1_YERPN;  A4TGU8, CYSG1_YERPP;  Q66EC9, CYSG1_YERPS;
DR   A0KP37, CYSG2_AERHH;  A4SRH0, CYSG2_AERS4;  A7MKK9, CYSG2_CROS8;
DR   A1WYD5, CYSG2_HALHL;  A6TF07, CYSG2_KLEP7;  Q6CZS0, CYSG2_PECAS;
DR   A8GKQ1, CYSG2_SERP5;  A1JSB7, CYSG2_YERE8;  A7FNS9, CYSG2_YERP3;
DR   Q1CCP6, CYSG2_YERPN;  A4TPZ1, CYSG2_YERPP;  Q664M6, CYSG2_YERPS;
DR   A0KQJ4, CYSG3_AERHH;  Q6F8G6, CYSG_ACIAD ;  B3GZA0, CYSG_ACTP7 ;
DR   B0BTC2, CYSG_ACTPJ ;  A6VPZ6, CYSG_ACTSZ ;  Q0VQ05, CYSG_ALCBS ;
DR   Q0A812, CYSG_ALKEH ;  C1DKY7, CYSG_AZOVD ;  Q1LTP4, CYSG_BAUCH ;
DR   Q7VQG9, CYSG_BLOFL ;  Q493N1, CYSG_BLOPB ;  Q2KWB0, CYSG_BORA1 ;
DR   Q7WMM4, CYSG_BORBR ;  Q7WB57, CYSG_BORPA ;  A9HZV6, CYSG_BORPD ;
DR   Q7VZ77, CYSG_BORPE ;  P57500, CYSG_BUCAI ;  Q7NZV7, CYSG_CHRVO ;
DR   A8AQS4, CYSG_CITK8 ;  A7ZSP4, CYSG_ECO24 ;  B7UK79, CYSG_ECO27 ;
DR   B7MCY5, CYSG_ECO45 ;  B7L4P2, CYSG_ECO55 ;  P0AEA9, CYSG_ECO57 ;
DR   B5YTS6, CYSG_ECO5E ;  B7NMD7, CYSG_ECO7I ;  B7N1F1, CYSG_ECO81 ;
DR   B7M1S1, CYSG_ECO8A ;  C4ZUM4, CYSG_ECOBW ;  B1X716, CYSG_ECODH ;
DR   A8A5H5, CYSG_ECOHS ;  A1AGQ2, CYSG_ECOK1 ;  Q0TC92, CYSG_ECOL5 ;
DR   Q8FCW8, CYSG_ECOL6 ;  B1IP96, CYSG_ECOLC ;  P0AEA8, CYSG_ECOLI ;
DR   B7NDX8, CYSG_ECOLU ;  B6I2S7, CYSG_ECOSE ;  B1LHG9, CYSG_ECOSM ;
DR   Q1R5R3, CYSG_ECOUT ;  C5BGP8, CYSG_EDWI9 ;  A4WFH1, CYSG_ENT38 ;
DR   B7LS75, CYSG_ESCF3 ;  A9H259, CYSG_GLUDA ;  Q5FP95, CYSG_GLUOX ;
DR   Q2SJB7, CYSG_HAHCH ;  Q31GG8, CYSG_HYDCU ;  Q65T49, CYSG_MANSM ;
DR   Q606C9, CYSG_METCA ;  Q1H3L5, CYSG_METFK ;  A9LZ77, CYSG_NEIM0 ;
DR   P57001, CYSG_NEIMA ;  P95370, CYSG_NEIMB ;  A1KU10, CYSG_NEIMF ;
DR   Q0AHC1, CYSG_NITEC ;  Q820Q4, CYSG_NITEU ;  Q2Y6L7, CYSG_NITMU ;
DR   Q3JCS0, CYSG_NITOC ;  Q7N8L2, CYSG_PHOLL ;  Q6LM67, CYSG_PHOPR ;
DR   Q48H75, CYSG_PSE14 ;  Q15YU1, CYSG_PSEA6 ;  A6V4H6, CYSG_PSEA7 ;
DR   B7UW11, CYSG_PSEA8 ;  Q02NA3, CYSG_PSEAB ;  Q9I0M7, CYSG_PSEAE ;
DR   Q1IBC9, CYSG_PSEE4 ;  Q4K9V8, CYSG_PSEF5 ;  C3JY53, CYSG_PSEFS ;
DR   A4XUX3, CYSG_PSEMY ;  A5W1H7, CYSG_PSEP1 ;  Q3KA85, CYSG_PSEPF ;
DR   Q88FT3, CYSG_PSEPK ;  B1JBD9, CYSG_PSEPW ;  Q87ZT0, CYSG_PSESM ;
DR   Q3ILQ9, CYSG_PSET1 ;  Q4ZRL6, CYSG_PSEU2 ;  Q4FSU1, CYSG_PSYA2 ;
DR   Q1QAX7, CYSG_PSYCK ;  A1SRP9, CYSG_PSYIN ;  A5WEG6, CYSG_PSYWF ;
DR   A1AVU5, CYSG_RUTMC ;  Q21K21, CYSG_SACD2 ;  B5F8J0, CYSG_SALA4 ;
DR   A9MME5, CYSG_SALAR ;  Q57IZ5, CYSG_SALCH ;  B5FJQ1, CYSG_SALDC ;
DR   B5R2C7, CYSG_SALEP ;  B5R7N6, CYSG_SALG2 ;  B4TKQ4, CYSG_SALHS ;
DR   B4SVI1, CYSG_SALNS ;  Q5PLV8, CYSG_SALPA ;  A9MT45, CYSG_SALPB ;
DR   C0Q0F3, CYSG_SALPC ;  B5BH22, CYSG_SALPK ;  B4TY38, CYSG_SALSV ;
DR   Q8Z201, CYSG_SALTI ;  P25924, CYSG_SALTY ;  B2U3H4, CYSG_SHIB3 ;
DR   Q31VS0, CYSG_SHIBS ;  Q32AZ8, CYSG_SHIDS ;  Q0SZU8, CYSG_SHIF8 ;
DR   Q83JB3, CYSG_SHIFL ;  Q3YWQ3, CYSG_SHISS ;  Q2NVN0, CYSG_SODGM ;
DR   A4VLU6, CYSG_STUS1 ;  Q3SG32, CYSG_THIDA ;  B8GUD3, CYSG_THISH ;
DR   C4LAG5, CYSG_TOLAT ;  A5CXE4, CYSG_VESOH ;  B2I985, CYSG_XYLF2 ;
DR   Q9PF46, CYSG_XYLFA ;  B0U4X0, CYSG_XYLFM ;  Q87AI5, CYSG_XYLFT ;
DR   Q1C2P9, CYSG_YERPA ;  Q74Y23, CYSG_YERPE ;  Q5NRM4, CYSG_ZYMMO ;
DR   Q59294, HEM4_RUMJO ;  P42437, NASF_BACSU ;  Q51701, NIRE_PARDP ;
DR   O34744, SUMT_BACSU ;  O19889, SUMT_CYACA ;  Q46BL0, SUMT_METBF ;
DR   P29564, SUMT_METIV ;  Q58375, SUMT_METJA ;  P29928, SUMT_PRIMG ;
DR   Q9I2W4, SUMT_PSEAE ;  P37725, SUMT_PSEFL ;  O74468, SUMT_SCHPO ;
DR   P21631, SUMT_SINSX ;  P42451, SUMT_SYNE7 ;  Q55749, SUMT_SYNY3 ;
DR   P36150, SUMT_YEAST ;  Q42606, UPM1_ARATH ;
//