ENZYME entry: EC 18.104.22.168
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|S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate <=> S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate|
- This enzyme is involved in ubiquinone biosynthesis.
- Ubiquinones from different organisms have a different number of
prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-
9 in rat and ubiquinone-10 in human), and thus the natural substrate
for the enzymes from different organisms has a different number of
- However, the enzyme usually shows a low degree of specificity
regarding the number of prenyl units.
- For example, the human COQ3 enzyme can restore biosynthesis of
ubiquinone-6 in coq3 deletion mutants of yeast.
- The enzymes from yeast and rat also catalyze the methylation of
3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this
activity is classified as EC 22.214.171.124).
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
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